Immunoreceptors

描述(由申请人提供)： 免疫系统的细胞表面受体(免疫受体)已被证明是包括癌症和自身免疫性疾病在内的各种临床环境中非常有效的治疗靶点。例如，以免疫受体为靶点的有效的基于抗体的生物制品可以通过受体拮抗、下调和/或靶向受体承载细胞以被天然免疫系统破坏来发挥作用。为了充分发挥这一方法的潜力，需要对细胞表面受体结构-功能关系和信号传递有更全面的了解。当临床医生和科学家之间的互动通过有重点的会议最大化时，这一目标的进展可以最快地实现。我们申请NIH支持将于2008年8月3-8日在康涅狄格州纽黑文举行的FASEB关于“免疫受体”的会议。这次会议是从20世纪80年代初S以来每两年成功举办一次的一系列会议演变而来的，这些会议最初专注于免疫球蛋白恒定区(Fc)受体功能的问题。在最近的几次迭代中，会议的范围扩大到考虑包含Ig-折叠的其他免疫系统受体的功能。这次会议将汇集专家，尽管他们来自不同的学科，但对这一受体家族有共同的兴趣，包括：分子结构及其如何影响功能，这些受体在炎症、信号转导和临床开发中的作用。会议的目标包括这些学科的受精以及年轻、女性和少数族裔科学家在这些研究领域的参与。因此，在迄今确认的26名受邀发言者中，有5名是妇女，另外9名发言将征求提交摘要的年轻科学家的意见。主要主题将是1)分子结构-功能，2)膜结构域，3)分子间相互作用和近端信号，4)免疫突触，5)免疫受体在疾病中的作用，6)在炎症、自身免疫和癌症中的治疗应用。会议的结构是为了提供一个最佳的跨学科互动的机会，以及平衡地展示我们领域中最当代的主题和有争议的问题的最新信息。它的目的是促进翻译研究，以开发针对细胞表面分子的治疗化合物。FASEB关于“免疫受体”的会议将于2008年8月3-8日在纽黑文CT举行。会议将集中讨论免疫系统免疫球蛋白相关表面受体的结构、功能、生物学和治疗应用方面的当代问题。这次会议将汇集120-150名不同的科学家，包括所有年龄段的科学家、妇女和代表不足的少数族裔，以促进该领域前沿的基础和翻译研究。

DESCRIPTION (provided by applicant): Cell surface receptors of the immune system (immunoreceptors) have proven to be very effective therapeutic targets in a variety of clinical settings including cancer and autoimmune disease. For example effective antibody based biologicals targeted to immunoreceptors may act by receptor antagonism, down-regulation and/or targeting of receptor bearing cells for destruction by the innate immune system. To reach the full potential of this approach a more complete understanding or cell surface receptor structure-function relationships and signaling will be necessary. The progress toward this goal can be attained most rapidly when interactions among clinicians and scientists are maximized by focused conferences. We apply for NIH support for the 2008 FASEB conference on "Immunoreceptors" to be held in New Haven, CT, August 3-8, 2008. The conference evolved from a series of successful conferences held bi-annually since the early 1980's that originally focused on the question of immunoglobulin constant region (Fc) receptor function. In recent iterations, the scope of the meeting has broadened to consider function of other immune system receptors that contain Ig-folds. The conference will bring together experts who, although they come from different disciplines, share interests in this family of receptors including: molecular structure and how it informs function, the role of these receptors in inflammation, signal transduction and exploitation in the clinic. Goals of the conference include fertilization across these disciplines and involvement of young, female and minority scientists in these research areas. Thus among the invited 26 speakers confirmed thus far 5 are women and an additional 9 presentations will be solicited from young scientists who submit abstracts. Major themes will be 1) molecular structure-function, 2) membrane domains, 3) intermolecular interactions and proximal signaling, 4) immunological synapse, 5) the role of immunoreceptors in diseases and 6) therapeutic application in inflammation, autoimmunity and cancer. The conference is structured to provide an optimal opportunity for cross-discipline interaction as well as a balanced presentation of state of the art information on the most contemporary topics and contentious problems in our field. It is intended to nurture translational studies to develop therapeutic compounds targeted to cell surface molecules. The FASEB conference on "Immunoreceptors" will be held in New Haven CT between August 3-8, 2008. The conference will focus on contemporary problems in the structure, function, biology and therapeutic applications of immunoglobulin related surface receptors of the immune system. The conference will bring together 120-150 diverse scientists including all age groups, women and underrepresented minorities to stimulate basic and translational research at the leading edge of this area.