Integrated and Translational Training in Anesthesiology Research

描述(申请人提供)：在过去的40年里，麻醉师已经成为基础科学和临床研究的越来越重要的贡献者。为了有效，这项研究需要增加对基本生理学、药理学、遗传学、分子生物学、生物工程、流行病学和生物统计学的理解。如果麻醉学要继续改善为年龄越来越大的日益复杂的患者提供的护理的安全性，并继续吸引最有能力的护理提供者进入该专业，我们必须在临床护理和研究方面提供尽可能好的培训。我们认为，为了保持研究工作的临床相关性，将麻醉师培训为科学家是至关重要的。近年来科学发现的快速发展，为将基本科学发现直接应用于疾病患者提供了难得的机会。基础科学和临床研究方面的严格培训是优化这类转化性研究的关键。该计划的目标是为麻醉师提供基础和临床科学培训，作为其研究生临床培训计划的一个组成部分。这种培训将使麻醉师能够建立独立的调查职业生涯，致力于通过增进该领域的知识来改善对麻醉/危重患者的护理。这项提议概述了愿意并准备实现这一目标的多样化但有凝聚力的教职员工的资历。培训计划包括两年的连续培训，学员在神经科学、性别生物学、肺部生物学、心血管、肾脏、新陈代谢和疼痛等研究领域的教职员工的密切监督下工作。最初，受训者将学习研究技能，后来的重点将指向独立假设的产生、实验设计、数据分析、研究结果的陈述和竞争外部资金。研究机会由在培训博士后研究员方面有成功记录的教职员工提供，这些人员来自麻醉学内部以及其他合作的基础科学和临床部门：神经学、医学、神经科学、儿科、神经外科、病理学和生理学和药理学。这个项目的目的是培养学术麻醉师，他们将在整个本世纪提供学术领导。

DESCRIPTION (provided by applicant): Over the past 40 years, anesthesiologists have become increasingly important contributors to both basic science and clinical research. To be effective, this research has required an increased understanding of basic physiology, pharmacology, genetics, molecular biology, bioengineering, epidemiology, and biostatistics. If anesthesiology is to continue to improve the safety of care provided to an increasingly complicated group of patients of increasing age and to continue to attract the most competent care providers into the specialty, we must provide the best training possible, both in clinical care and research. We believe it is crucial to maintain training of anesthesiologists as scientists in order to maintain the clinical relevance of research endeavors. The rapid progression of scientific discovery in recent years, offers remarkable opportunities for direct application of basic scientific findings to patients with disease. Rigorous training in both basic science and clinical research is the key to optimize this type of translational research. The goal of this program is to provide basic and clinical scientific training to academic anesthesiologists as an integral component of their postgraduate clinical training program. This training will allow anesthesiologists to establish independent investigative careers devoted to improving care of the anesthetized/critically ill patient by advancing knowledge in the field. This proposal outlines the credentials of a diverse but cohesive faculty who are willing and prepared to meet this objective. The training program involves a two year continuum where trainees work under close supervision of a faculty member in research areas of neuroscience, gender biology, lung biology, cardiovascular, kidney, metabolism, and pain. Initially, the trainee will learn research skills, and later emphasis will be directed towards independent hypothesis generation, experimental design, data analysis, presentation of research findings, and competition for external funding. Research opportunities are offered by faculty members with proven records of success in the training of postdoctoral fellows, both from within Anesthesiology as well as from other collaborating basic science and clinical departments: neurology, medicine, neuroscience, pediatrics, neurosurgery, pathology, and physiology & pharmacology. This program is designed to produce academic anesthesiologists who will provide academic leadership throughout this century.