Training Program in Molecular and Cellular Toxicology

描述（由申请人提供）人类暴露于环境和职业毒物的后果是一个全球性问题。随着时间的推移，毒理学领域已经认识到慢性低剂量暴露与疾病发展之间的关系。随着分子和细胞生物学、重组DNA技术、生物信息学和分子遗传学的出现，生物医学科学变得更加复杂和跨学科。存在着将环境引起的疾病与遗传、生化和分子机制联系起来的独特机会。因此，重要的是培训当前和未来的科学家掌握当今科学的技术，并为他们提供科学基础，使他们能够利用这些技术来解决环境健康问题。环境健康科学研究所（IEHS）是韦恩州立大学组织结构中的一个独立单位，重点研究毒物效应的分子、细胞和基因组方法。作为NIEHS p30支持的环境健康科学（EHS）中心的总部，环境健康科学中心是促进、发展和协调毒理学教学以及研究环境因素与人类疾病之间关系的中心。IEHS也是分子和细胞毒理学跨学科博士预科项目的总部。与该培训项目相关的11名教员来自环境与健康安全研究院和环境与健康安全中心。这项T32资助将重点培养2名分子和细胞毒理学项目的博士生。对从这个跨学科研究生项目中选出的学生的培训将通过2-3年的任命来加强niehs赞助的培训补助金。这些学生将接受强化教学，使他们：1)精通毒理学原理，但认识到该领域的跨学科性质；2)获得生命科学中使用的许多当代技术和技术的专业知识；3)认识和理解环境、遗传学/基因组学、对毒物的易感性和人类疾病的发展和进展之间的复杂关系。分子和细胞毒理学博士预科课程的总体目标是培养独立的科学家，他们为环境健康研究做好了充分的准备，并有能力利用分子生物学、细胞生物学、基因组学和遗传学的当代概念、方法和技术进行有竞争力的研究。预计经过此类培训的学生将更有能力在美国各大研究实验室进行博士后研究。

DESCRIPTION (provided by applicant) The consequences of human exposure to environmental and occupational toxicants are a global issue. Over time, the field of toxicology has come to recognize the relationship between chronic low dose exposure, and the development of disease. With the emergence of molecular and cellular biology, recombinant DNA technology, bioinformatics, and molecular genetics, biomedical science has become more complex and interdisciplinary. Unique opportunities exist to relate environmentally caused disorders to genetic, biochemical and molecular mechanisms. Therefore, it is important to train current and future scientists in the technologies of today's science, and give them the scientific foundation that will enable them to use the technologies to address environmental health issues. The Institute of Environmental Health Sciences (IEHS) is a free-standing unit within the organizational structure of Wayne State University with a focus on molecular, cellular, and genomic approaches to the study of toxicant effects. As the headquarters of a NIEHS P30-supported Environmental Health Science (EHS) Center, the IEHS functions as a focal point for stimulating, developing and coordinating instruction in toxicology, and studying the relationship between environmental factors and human disease. The IEHS is also the headquarters of an interdisciplinary pre-doctoral program in Molecular and Cellular Toxicology. The 11 faculty associated with this training program are drawn from the IEHS and the EHS Center. This T32 grant will focus on the training of 2-predoctoral students in the Molecular and Cellular Toxicology Program. The training of students selected from this interdisciplinary graduate program will be augmented by a 2-3 year appointment to the NIEHS-sponsored training grant. These students will receive intensive instruction such that they: 1) are versed in the principals of toxicology but recognize the cross disciplinary nature of the field; 2) gain expertise with many of the contemporary techniques and technologies used in the life sciences; and 3) recognize and appreciate the complex relationships between environment, genetics/genomics, susceptibility to toxicants, and the development and progression of human disease. The overall goal of the predoctoral program in Molecular and Cellular Toxicology is to develop independent scientists who are well prepared for environmental health research, and equipped to perform competitive research using contemporary concepts, approaches and the technologies of molecular biology, cell biology, genomics and genetics. It is envisioned that students with such training will be better equipped to pursue postdoctoral research at major research laboratories throughout the United States.