Molecular Biophysics Training Grant

描述（由申请人提供）：本申请要求继续支持分子生物物理学博士培训计划，该计划目前已经存在了10年。本提案中的培训教师主要在两个密切相关的部门，生物化学和生理与生物物理学中任命。通过必修和选修课程，参加研究研讨会和讨论小组，最重要的是，通过个人研究，学生学员培养了进行分子生物物理学独立研究所需的技术技能和批判能力。培训包括三到四年的个人研究，通常有联合指导，第一年完全由课程和实验室轮岗组成。每个学生的课程作业和研究训练都受到该计划指导委员会的密切监控。在指导委员会的指导下，培训教师和学员定期召开会议，以及所有学员参加的核心课程，确保了项目的凝聚力。该项目为分子生物物理学的学生提供了宝贵的培训机会，因为该机构拥有优秀的教师和设施，特别是在两个领域，该项目提供了无与伦比的机会。其中包括同步加速器和激光光谱学研究。由国家同步加速器光源医学院操作的光束线设备包括学生使用最先进的蛋白质晶体学、x射线吸收光谱、x射线足迹和红外微光谱技术。此外，学院的激光设备包括几个实验室，拥有最先进的飞秒到微秒时间分辨仪器，用于研究蛋白质折叠和动力学，供学生研究。在培训师的实验室中，特别强大的研究领域是结构生物学，包括大分子核磁共振和晶体学，蛋白质和核酸折叠和蛋白质动力学的时间分辨研究；金属蛋白、金属酶和酶的结构功能关系本课题所涉及的两个系目前正在吸引优秀的实习候选人，并在过去培养了许多成绩优异的学生。该项目目前每年培养6名博士预科生；这项建议建议每年增加到7个名额。

DESCRIPTION (provided by applicant): This application requests continued support for a Ph.D. Training Program in Molecular Biophysics, which is currently in its tenth year of existence. The training faculty in this proposal primarily have appointments in two closely allied departments, Biochemistry and Physiology & Biophysics. Through required and elective courses, participation in research seminars and discussion groups and, most importantly, through individual research, the student trainees develop the technical skills and critical ability necessary to conduct independent research in Molecular Biophysics. Training consists of three to four years of individual research, often with joint mentoring, after a first year that consists entirely of coursework and laboratory rotations. Both the course work and research training of each student are closely monitored by the Steering Committee for the program. The cohesiveness of the program is assured by regular meetings of the training faculty and trainees under the guidance of the Steering Committee as well as by Core courses taken by all trainees. This program provides valuable training opportunities for students in Molecular Biophysics due to the outstanding faculty and facilities that exist at the Institution In two areas in particular, the program provides unparalleled opportunities. These include synchrotron and laser spectroscopy research. Beamline facilities operated by the College of Medicine at the National Synchrotron Light Source include student access to state-of-the art protein crystallography, x-ray absorption spectroscopy x-ray footprinting, and infrared microspectroscopy techniques. Also, the laser facilities of the College include several laboratories with state-of-the art femtosecond to microsecond time-resolved instrumentation for the study of protein folding and dynamics for student research. The research areas that are especially strong in the trainer's laboratories are Structural Biology, including macromolecular NMR and crystallography time-resolved investigations of protein and nucleic acid folding and protein dynamics; structure function relationships of metalloproteins, metalloenzymes, and enzymes; and allostenc interactions of macromolecules The two departments involved in this proposal are currently attracting excellent trainee candidates and have trained numerous students in the past who have excellent outcomes. The program currently provides training for six pre-doctoral students in each year; this proposal suggests an increase to seven slots per year.