Postdoc Training in Translational Research in Neural Injury and Neurodegeneration

描述（由申请人提供）： 我们提出了在神经损伤和神经退行性变的转化研究的医学博士或MD-PhDs谁完成神经病学，神经外科，精神病学，眼科，麻醉，急诊医学或任何其他临床神经科学专业的临床培训的综合培训计划，并希望在疾病的神经生物学实验室为基础的转化研究的学术生涯。临床科学家有一个独特的能力，提出新的科学问题的灵感来自病人的观察，并处于独特的沟通和合作与博士科学家和医疗保健提供者。该计划是围绕指导关系，其中两个经验丰富的教师培训师指导学员的研究发展。将挑选导师为学员提供补充经验。学员将有机会进入宾夕法尼亚大学教师“核心”小组内的至少22个实验室，但也可以在其他实验室进行培训。学员研究必须是合作性的，提出至少与两个群体相关的问题。为期2年的计划将专注于急性和慢性神经退行性疾病和病症的神经保护，包括中风;脑和脊髓损伤;阿尔茨海默氏症，帕金森氏症和运动神经元疾病;癫痫;视网膜变性;抑郁症;行为障碍;自闭症。培训将重点放在实验室研究上，学员项目旨在了解遗传，分子和细胞病理生理学以及预防，治疗或治愈策略的发展。教学培训将包括：课程在大学的综合疾病神经生物学课程和研讨会在临床试验方法，拨款准备，统计，生物伦理学，以病人为导向的研究，和新药开发。该计划将开始与2名学员，增长到5个在2年内。拟议计划的一个独特之处是，未来的受训者将在临床培训结束前就知道他们被接受。这将使学员能够利用住院期间的时间来规划其专业发展的这一阶段，以获得研究和研究相关的经验，最终扩大他们在撰写K奖提案之前获得的培训总量。预计完成该计划的学员将非常有竞争力的独立研究补助金，将成为学术医疗中心的教员，并将从事疾病神经生物学的转化研究。相关性：我们建议教医生进行实验室研究神经系统疾病的原因。更好的理解将导致新的治疗和治疗方法的发展。

DESCRIPTION (provided by applicant): We propose an integrative training program in translational research in neural injury and neurodegeneration for MDs or MD-PhDs who finish clinical training in Neurology, Neurosurgery, Psychiatry, Ophthalmology, Anesthesia, Emergency Medicine or any other clinical neuroscience specialty, and desire academic careers in laboratory-based translational research in the Neurobiology of Disease. Clinician-scientists have a unique ability to ask new scientific questions inspired by patient observations, and are singularly situated to communicate and collaborate with both PhD scientists and health care providers. The program is built around mentoring relationships in which two experienced faculty trainers guide a trainee's research development. Mentors will be chosen to offer complementary experience to the trainee. Trainees will have access to a minimum of 22 laboratories within the "core" group of Penn faculty, but could train in other laboratories as well. Trainee research must be collaborative, asking questions relevant to at least two groups. The 2-year program will focus on neuroprotection for acute and chronic neurodegenerative diseases and conditions, including stroke; brain and spinal cord injury; Alzheimer's, Parkinson's and motor neuron diseases; epilepsy; retinal degeneration; depression; behavioral disorders; autism. Training will focus heavily on laboratory research, with trainee projects directed toward understanding the genetic, molecular and cellular pathophysiology and the development of strategies for prevention, treatment, or cure. Didactic training will include: coursework in the University's comprehensive Neurobiology of Disease curriculum and workshops in clinical trial methodology, grant preparation, statistics, bioethics, patient-oriented research, and new drug development. The program would begin with 2 trainees, growing to 5 within 2 years. A unique feature of the proposed Program is that prospective trainees will know of their acceptance into the Program well before their clinical training ends. This will allow trainees to plan for this stage of their professional development by taking advantage of the time during residency to gain research, and research-related experience, with the final effect of expanding the total amount of training they will have acquired before writing their K-award proposal. It is expected that trainees who complete this program will be very competitive for independent research grant funding, will become faculty members at academic medical centers, and will pursue careers in translational research in the neurobiology of disease. Relevance: We propose to teach physicians to conduct laboratory research into causes of neurological diseases. A better understanding will lead to the development of new treatments and cures.