Rhinosinusitis in Asthma

描述(由申请人提供)： 这位候选人是佛蒙特州大学的肺部和重症监护医学助理教授。在担任研究员期间，她成功地完成了免疫介导的肺损伤小鼠模型的研究，但现在决定从事以患者为导向的研究，以符合她对哮喘的临床兴趣。她的长期职业目标是成为应用哮喘研究领域的一名独立研究员。她的研究兴趣是确定上呼吸道疾病(鼻炎和鼻窦炎)是否会加重哮喘。为了实现她的职业目标，她为目前的申请制定了非常具体的教育目标。候选人将通过佛蒙特大学参加生物统计学和伦理学的课程，并通过约翰霍普金斯大学彭博公共卫生学院进行更高级的流行病学和临床研究培训。她还将参加免疫学课程，为她的研究生涯计划中的翻译部分做好准备。她将进行受到密切监督的研究项目，这些项目将使她在所需技能方面获得实践经验：这些项目旨在为她提供流行病学实践培训、临床试验表现以及研究哮喘受试者上、下呼吸道炎症和功能变化的实验室方法培训。她将在现有的数据集中初步建立上呼吸道疾病和哮喘临床特征之间的联系。然后，她将进行一项以普通临床研究中心为基础的前瞻性研究，以确定炎症和上呼吸道功能变化与哮喘之间的关系。最后，她提出了一项小规模随机对照试验，以确定在衡量下呼吸道疾病方面治疗上呼吸道疾病的效果。目前的提案将为她在哮喘领域面向患者的翻译研究领域的独立职业生涯做好准备。同时，它将促进我们对哮喘上、下呼吸道之间联系的理解，这些研究的结果将指导医生照顾哮喘患者。

DESCRIPTION (provided by applicant): The candidate is an Assistant Professor of Pulmonary and Critical Care Medicine at the University of Vermont. She successfully completed research on a murine model of immune-mediated lung injury during her fellowship, but has now decided to pursue a career in patient-oriented research, in line with her clinical interest in asthma. Her long-term career goal is to become an independent investigator in the field of applied asthma research. Her research interest is to establish if disease in the upper airway (rhinitis and sinusitis) worsens asthma. To achieve her career goals, she has very specific educational goals for the current application. The candidate will take classes in biostatistics and ethics through the University of Vermont, and complement this with more advanced training in epidemiology and clinical research through the Johns Hopkins University Bloomberg School of Public Health. She will also take courses in Immunology to prepare her for the translational component of her research career plan. She will undertake closely supervised research projects that will give her practical experience in the skills she requires: these projects are designed to give her practical training in epidemiology, the performance of clinical trials, and training in laboratory methods to study inflammation and functional changes in the upper and lower airway of asthmatic subjects. She will initially establish the association between upper airway disease and clinical characteristics of asthma in an existing data set. She will then undertake a prospective General Clinical Research Center based study to determine the relationship between inflammation and functional changes in the upper airway and the presence of asthma. Finally she proposes a small-randomized-controlled trial to determine the efficacy of treating upper airway disease on measures of lower airway disease. The current proposal will prepare her for an independent career in patient-oriented translational research in the field of asthma. At the same time it will advance our understanding of the link between the upper and lower airway in asthma and the results of these studies will guide physicians caring for asthmatic patients.