Bay Area Breast Cancer & the Environment Research Center

乳腺癌仍然是女性最常见的癌症，也可能是她们最害怕的医疗诊断。 尽管人们对乳腺癌的病因已知很多，但关于环境因素的问题仍然存在 启动乳腺癌的致癌过程以及它们在生命周期中的作用。湾区乳腺癌和 总部设在加州大学旧金山分校的环境研究中心(BABCERC) 在人口科学主任罗伯特·A·希亚特博士的领导下，巨大的癌症中心，威尔·阿德尔斯， 对乳腺癌的环境病因学的关注主要集中在乳腺的发展-- 在青春期，乳房可能特别容易受到环境影响。在同一时间 它将建立一个独特的组织基础设施，以加强现有的科学家与当地 社区和倡导团体遵循以社区为基础的参与性研究的原则。湾区 该地区非常适合建立这样一个中心，因为据报道，那里的乳腺癌发病率是全国最高的 国家和有关社区成员、政府领导人、卫生部门的高度关注和合作 各部门、学术机构和倡导团体。项目1将研究乳腺细胞和乳腺 在正常和易患癌症的小鼠发育的所有阶段确定微环境的影响 在这个模型中暴露于典型的环境应激源，并开发基于体外机制的筛选来 检测可能具有乳腺致癌作用的物质。项目2提议招募一批 来自凯撒基金会健康计划的大约400名7-8岁女孩，并跟踪她们完成 青春期过渡。数据将在6年的随访期内从问卷、实物调查中收集 检查和生物检疫，以分析环境因素和乳房之间的联系 发展，包括与选定的基因环境有关的易感性的可能重要性 互动。社区外展和翻译核心将由以下领导人指导和组成 马林县和旧金山县的当地乳腺癌倡导运动，他们都很有经验 与他们各自的社区就这项研究的主题进行合作。COTC的活动都很高 与研究项目整合和互动，并与社区及其关注的问题很好地联系起来。通过 融合了发育生物学、流行病学、 和社区倡导，BABCERC将提供一个令人兴奋的机会，对 重大的社会和生物医学挑战……了解乳腺癌与环境的关系。

Breast cancer remains the most common cancer for women and perhaps their most feared medical diagnosis. Although much is known about the etiology of breast cancer, questions remain about environmental factors that initiate breast cancer carcinogenesis and when they act during the lifespan. The Bay Area Breast Cancer and the Environment Research Center (BABCERC), based at the University of California San Francisco Compre- hensive Cancer Center under the leadership of Dr. Robert A. Hiatt, Director of Population Sciences, will addres., the on-going concerns about the environmental etiology of breast cancer by focusing on mammary gland develop- ment during puberty when the breast may be especially vulnerable to environmental influences. At the same time it will create a unique organizational infrastructure for enhancing the existing partnership of scientists with local community and advocacy groups following the principles of community-based participatory research. The Bay Area is well suited for such a Center because rates of breast cancer there have been reported as the highest in the nation and there is high interest and cooperation from involved community members, government leaders, health departments, academic institutions and advocacy groups. Project 1 will study mammary cells and the mammary microenvironment in normal and cancer prone mice during all stages of development to determine the effects of exposure to prototypical environmental stressors in this model and develop in vitro mechanism-based screens to detect agents with possible mammary gland carcinogenicity. Project 2 proposes to recruit a cohort of approximately 400 7-8 year old girls from the Kaiser Foundation Health Plan and follow them through the pubertal transition. Data will be collected during a 6 year follow-up period from questionnaires, physical examination, and biospecimens that will allow analyses of links between environmental factors and mammary development, including the possible importance of susceptibility associated with selected gene-environment interactions. The Community Outreach and Translational Core will be directed and comprised of leaders in the local breast cancer advocacy movements in Marin and San Francisco Counties, who are highly experienced working with their respective communities on the topic of this research. The COTC activities are both highly integrated and interactive with the research projects and well connected to the community and its concerns. By incorporating the skills of a broad spectrum of expertise in fields such as developmental biology, epidemiology, and community advocacy, the BABCERC will provide an exciting opportunity for transdisciplinary research on a significant societal and biomedical challenge...understanding the relationship of breast cancer to the environment.