Retrovirology Services

核心H：逆转录病毒学服务 Lifespan/Tufts/Brown CFAR的逆转录病毒学服务核心（核心H）的具体目标是（1） 为CFAR调查人员提供基本的病毒学实验室服务，以支持他们以HIV-1为中心的基本 科学调查，重点是初级调查人员和那些接受过CFAR的个人 发展补助金，（2）处理和存档来自正在进行的单个和多个地点的临床标本 试验（AACTG、HPTN、HVTN、SUN），以及（3）促进艾滋病毒-1基础科学培训/教育， CFAR机构的博士后学生和参加布朗/塔夫茨大学的个人 福格蒂艾滋病国际研究培训计划（D43 TW 000237）。核心开始运作， 2002年9月，在过去的4年里， 强大的实验室支持。这一基础设施最近已部分用于七个 招募了从事HIV-1病毒学各个方面工作的初级研究人员。这七个人 获得新的联邦和/或私人资金用于他们的各种项目。目前， 核心用户分为以下几大类：杀微生物剂的设计和交付，抗逆转录病毒药物的发展 资源贫乏地区的耐药性，开发针对HIV-1和相关疾病的新的治疗方法， 恶性肿瘤和感染，HIV-1生殖器负荷的特征，设计最佳HIV-1治疗 在难以接触的人群或居住在资源贫乏地区的人群中的范例， HIV-1感染的自然史在当前的授权期内，核心将保持所有当前的分析 和存档功能，并扩大服务范围，为基于RNAi的分析提供工具。在 此外，该中心还将协助研究人员进行小动物实验，以支持NIH 资助对杀微生物剂设计和投放的调查。核心将继续管理50，000 + 临床样本的存档，并支持CFAR教师追求新的临床试验。芯会 继续为最近获得资助的研究者提供按服务收费的分析支持，并继续 支持那些没有获得独立资助的初级教师的有价值的项目。

Core H: Retrovirology Services The specific aims of the Retrovirology Services Core (Core H) of the Lifespan/Tufts/Brown CFAR are to (1) Provide basic virology laboratory services to CFAR investigators in support of their HIV-1 centered basic science investigation with emphasis on junior investigators and those individuals who have received CFAR developmental grant awards, (2) Process and archive clinical specimens from ongoing single and multi-site trials (AACTG, HPTN, HVTN, SUN), and (3) Facilitate the HIV-1 basic science training/education of pre- and postdoctoral students at CFAR institutions and those individuals participating in the Brown/Tufts University Fogarty AIDS International Research Training Program (D43TW000237). The Core began operations in September of 2002 and over the past 4 years has created and maintained 3500 square feet of new laboratory space with strong institutional support. This infrastructure has been used in part by seven recently recruited junior investigators working on various aspects of HIV-1 virology. All seven individuals have received new federal and/or private funding for their various projects. Presently, the research interests of Core users fall into the following broad categories: Microbicide design and delivery, Evolution of antiretroviral resistance in resource-poor areas, Development of novel therapeutic approaches to HIV-1 and related malignancies and infections, Characterization of HIV-1 genital burden, Designing optimum HIV-1 treatment paradigms in hard-to-reach populations or those residing in resource poor areas and, Longitudinal studies of the natural history of HIV-1 infection. In the current granting period, the Core will maintain all current assay and archiving capabilities and expand the range of services to provide tools for RNAi based assays. In addition, the Core will assist investigators in performing experiments with small animals in support of NIH funded investigations of microbicide design and delivery. The Core will continue to manage the 50,000+ archive of clinical samples and support the pursuit of new clinical trials by CFAR faculty. The Core will continue to offer assay support to recently funded investigators on a fee-for-service basis and continue to support meritorious projects by junior faculty who have not garnered independent grant support.