From Dynamic Combinatorial to Systems Chemistry

动态组合化学领域在过去十年中呈指数级增长，英国发挥了主导作用。在过去的10年里，由于EPSRC不间断的支持，我们一直处于快速扩张的最前沿。因此，动态组合化学现在是开发合成受体的一种强大而成熟的方法。但这只是动态组合化学的一部分前景：该技术在很大程度上具有未开发的潜力，可以利用库成员之间的分子识别来探索自组装，也可以利用库成员内部的分子识别来探索合成分子的折叠。分子识别的这两个维度都应该响应外部添加的模板，这代表了识别的第三个维度。这项资助的第一部分是关于发展动态组合化学来研究这三个维度之间的相互作用。第二部分探讨了系统化学概念上的新领域，重点关注复杂混合物中分子之间相互作用可能产生的新性质。通过这项工作，我们的目标是建立系统化学作为一个新的学科。

The field of dynamic combinatorial chemistry has been growing exponentially over the last decade, with the UK playing a leading role. We have been at the forefront of this rapid expansion, thanks to uninterrupted support from the EPSRC over the last 10 years. As a result, dynamic combinatorial chemistry is now a powerful and established method for the development of synthetic receptors. But this is only part of the promise that dynamic combinatorial chemistry holds: the technique has largely untapped potential for exploring self-assembly by making use of molecular recognition between library members and for exploring the folding of synthetic molecules by making use of molecular recognition within library members. Both of these dimensions of molecular recognition should respond to externally added templates, which represents a third dimension of recognition. The first part of this grant is about developing dynamic combinatorial chemistry to study the interplay between these three dimensions. The second part explores a conceptually new area of systems chemistry, focussing on the new properties that may emerge from the interplay between molecules in a complex mixture. Through this work we aim to establish systems chemistry as a new discipline.