Functional Tissue Replacement and Substitution: Platform Grant

我们在功能组织替代和替代方面的研究既满足了主要的社会需求，也满足了全球经济机遇。它对从功能生物材料和设备到组织工程构造的一系列医疗干预措施产生影响。它主要侧重于肌肉骨骼和心血管系统的退行性缺陷和老化，融合了物理和生物科学和技术，以应对国家和国际机会。特别是，它通过提供维持行动能力和减轻疼痛的设备和治疗干预措施，满足了退休年龄延长、工作寿命延长和寿命延长的功能性老龄化人口的主要社会需求。我们的研究满足了患者对早期干预、快速康复、增加的功能需求和个性化解决方案的日益增长的期望。这将通过研究和开发能够实现组织保存和再生能力以及更快地恢复自然生物力学功能的设备和疗法来实现。它将应用生物科学和纳米技术的最新进展，通过系统工程方法将这一多学科的科学整合到新技术发现和产品创新中。研究计划将建立在我们之前在髋关节和膝关节置换磨损方面的研究基础上，在这些研究中，我们研究和开发了新的材料和设计，为年轻和活跃的患者提供更持久的关节。它将解决部分关节置换、软骨置换和组织工程学的新方法，这些方法有可能提供早期干预、组织保留和微创外科治疗。它还将通过骨保护和增强疗法以及新的关节植入物和椎间盘置换解决脊柱中的功能性组织替代问题。在脊椎中尤其重要的是功能模拟系统的开发，以便在实验室和计算机模型中复制体内发现的复杂结构和功能。在心血管系统中，将通过实验室和临床模型研究新型仿生组织支架，为血管和心脏瓣膜提供功能性组织再生解决方案。

Our research in functional tissue replacement and substitution addresses both major societal needs and global economic opportunities. It impacts upon a spectrum of medical interventions from functional biomaterials and devices to tissue engineered constructs. It primarily focuses on degenerative deficiencies and ageing in the musculoskeletal and cardiovascular systems, by converging physical and biological sciences and technologies to address national and international opportunities. In particular it addresses the major societal needs of the functional ageing population, which has an increased retirement age, extended working life and increased longevity, by providing devices and therapeutic interventions to sustain mobility and relieve pain. Our research addresses increased patient expectation for earlier intervention, rapid rehabilitation, increased functional demand and personalized solutions.This will be delivered though research and development of devices and therapies that enable tissue preservation and regenerative capacity and more rapid restoration of natural biomechanical function. It will apply recent advances in biological sciences and nanoscale technologies, integrating this multidisciplinary science through a systems engineering approach to new technology discovery and product innovation.The program of research will build upon our previous research in wear of joint replacements in the hip and knee, in which we have researched and developed new materials and designs to provide longer lasting joints for young and active patients. It will address new approaches to partial joint replacement, cartilage substitution and tissue engineering, which have the potential to provide earlier intervention, tissue sparing and minimally invasive surgical therapies. It will also address functional tissue substitution in the spine, through bone preserving and augmentation therapies and new articulating implants and disc replacements. Particularly important in the spine is the development of functional simulation systems to replicate in the laboratory and in computer models the complex structure and function found in vivo. In the cardiovascular system novel biomimetic tissue scaffolds, which provide functional tissue regeneration solutions for blood vessels and heart valves, will be researched, through laboratory and clinical models.