Second International Brainstorming Meeting on Parkinson Disease: Nosology

描述（由申请人提供）：本申请为“第二届帕金森氏病国际头脑风暴会议：分类学”寻求支持，该会议定于5月16日至17日在肯塔基州路易斯维尔举行。本次会议的主要目标是汇集来自不同研究背景的世界知名临床和基础科学家专家，就特发性帕金森病（PD）的分类学进行头脑风暴，并完善其诊断标准。PD的死前诊断没有生物学标记物。PD误诊是常见的，特别是在早期阶段。最近对PD的非运动方面和黑质外变性的了解增加了对该疾病的了解，但这些发现也挑战了当前的临床诊断标准。此外，鉴于PD遗传学的最新进展（即α -突触核蛋白三重和重复），需要澄清痴呆是否属于PD谱系的一部分。此外，由于一些由基因决定的帕金森综合征，有时与帕金森病非常相似，但在神经病理学上有所不同；需要阐明的是，路易小体是否需要用于神经病理学PD的定义。很明显，PD在临床、病理和病因上是多种多样的，但各种实体尚未完全一致。由于在遗传学、流行病学或临床药物试验中，只有明确定义的人群才能得出确切的结论，鉴于当前的科学进步，反思PD的病分学并重新定义该疾病的临床和病理诊断标准是至关重要和及时的。国际专家将涵盖病理学、遗传学、分子生物学、运动障碍、神经影像学、神经心理学、神经行为学和神经流行病学等领域。本次会议还将邀请初级研究人员在海报会议上介绍正在进行的研究，并将为他们提供与高级科学家互动的绝佳机会。讨论将集中在当前的知识、当前研究的注意事项和未来的研究需求，为新的合作和新的研究建议以及PD的临床和神经病理学诊断标准的修订提供机会。本次会议的结果将发表在同行评议的期刊上，预计这将使人们对PD有更深入的了解和理解，从而有助于推动该领域的发展。PI在组织这类会议方面有丰富的经验，并在同行评议期刊上发表了被高度引用的文章。本次会议得到了运动障碍学会和路易斯维尔大学的支持，NINDS的支持对其成功和传播至关重要，最近或未来没有关于该主题的会议。公共卫生相关性：本次会议的主要目标是汇集来自不同研究背景的临床和基础科学家专家，就特发性帕金森病（PD）的分类学进行头脑风暴，并完善其诊断标准。

DESCRIPTION (provided by applicant): This application seeks support for the "Second International Brainstorming Meeting on Parkinson disease: Nosology," scheduled for May 16th and 17th, in Louisville, KY. The main goal of this conference is to bring together world-known clinical and basic scientist experts from various research backgrounds to brainstorm on the nosology of idiopathic Parkinson's disease (PD) and refine its diagnostic criteria. There are no biological markers for the pre-mortem diagnosis of PD. PD misdiagnosis is frequent, particularly at early stages. Recent understanding of the non-motor aspects of PD and degeneration outside the substantia nigra has increased the understanding of the disorder, but these findings have also challenged current clinical diagnostic criteria. Moreover, in view of recent advances in PD genetics (i.e., alpha-synuclein triplications and duplications), it needs to be clarified if dementia is part of the spectrum of PD. Further, since some genetically determined Parkinson syndromes, sometimes closely resemble, PD, but differ from it neuropathologically; it needs to be elucidated if Lewy bodies are required for the neuropathologic PD definition. It is clear that PD is diverse clinically, pathologically, and etiologically diverse, but the various entities have not been fully agreed upon. Since only well defined populations lead to firm conclusions in genetic, epidemiologic or clinical drug trials, it is crucial, and timely, in view of current scientific advances, to reflect on the PD nosology and to redefine the set of clinical and pathologic diagnostic criteria for this disorder. International experts will cover the fields of pathology, genetics, molecular biology, movement disorders, neuroimaging, neuropsychology, neurobehavior and neuroepidemiology. This conference will also engage junior investigators to present ongoing research at poster sessions and will provide an excellent opportunity for them to interact with senior scientists. Discussions will center on current knowledge, caveats of current studies, and future research needs, providing opportunities for new collaborations and new study proposals as well as revisions of clinical and neuropathologic diagnostic criteria for PD. The results of this conference will be published in a peer-reviewed journal and it is anticipated that this will allow gaining a greater insight and understanding of PD that will help move the field forward. The PI has extensive experience in organizing this type of meetings that have led to highly cited publications in peer-review journals. This conference has the support of the Movement Disorder Society and the University of Louisville and NINDS support is critical to its success and dissemination, there are no recent or future conferences on this topic. PUBLIC HEALTH RELEVANCE: The main goal of this conference is to bring together clinical and basic scientist experts from various research backgrounds to brainstorm on the nosology of idiopathic Parkinson's disease (PD) and refine its diagnostic criteria.