RADIOLABELING/DOSIMETRY

描述（由申请人提供）：放射性标记/成像/剂量测定共享设施是 该公司成立于1994年，作为放射性标记共享机构，为体外实验室研究、体内动物模型研究和体内人体临床方案提供放射性标记服务。 该机构在广泛的放射性同位素的放射性标记程序方面拥有丰富的经验，并提供适当的质量控制程序，以确保癌症中心成员的标准化和高质量试剂。 该设施生产供“人用”的放射性标记试剂，包括用于大剂量治疗性放射性研究试剂的安全程序。 设施能力的扩展，包括2001年购买的AXIS（Picker International/Marconi）双头摄像机成像系统，为我们的免疫治疗计划提供了高质量的成像和剂量估算分析。 这些额外能力的发展使该设施在我们的转化研究和靶向免疫治疗工作中发挥了重要作用。 该设施为CCC成员提供与蛋白质、肽和寡核苷酸放射性标记相关的咨询服务。此外，该设施还提供集中的 购买同位素，这使得CCC成员的研究资金得到非常具有成本效益的利用。 该机构负责华莱士肿瘤研究所的放射废物管理，包括废物产生和处置的获取、利用和记录。 该机构根据FDA、州和其他监管机构的要求，提供所有人用放射性标记试剂的文件。 放射性标记/成像/剂量测定共享设施是癌症中心与UAB辐射安全部门和废物管理小组的接口。

DESCRIPTION (provided by applicant): The Radiolabeling/Imaging/Dosimetry Shared Facility was established in 1994 as the Radiolabeling Shared Facility in order to provide radiolabeling services for in vitro laboratory studies, in vivo animal model investigations and in vivo human clinical protocols. The facility has extensive experience with radiolabeling procedures for a wide range of radioactive isotopes and provides appropriate quality control procedures to assure standardized and high quality reagents to Cancer Center members. The facility generates radiolabeled reagents for "human use" including safety-oriented procedures for large doses of therapeutic radioactive investigational agents. The expansion of the facilities capabilities, including the purchase of an AXIS (Picker International/Marconi) dual-head camera imaging system in 2001, provides high quality imaging and dosimetry estimate analysis for the protocols in our immunotherapy program. The development of these additional capabilities has allowed the facility to play an important role in our translational research and targeted immunotherapy efforts. The facility provides consultation services related to radiolabeling of proteins, peptides and oligonucleotides to CCC members, hi addition, the facility provides a centralized purchasing of isotopes, which leads to a very cost-effective utilization of research funds for CCC members. The facility has responsibility for radiation waste management in the Wallace Tumor Institute including acquisition, utilization and documentation of waste generation and disposal. The facility provides documentation of all radiolabeled reagents for human use according to FDA, state and other regulatory agencies. The Radiolabeling/Imaging/Dosimetry Shared Facility is the Cancer Center's interface with the Radiation Safety Department and Waste Management group of UAB.