Identification and characterisation of a novel genetic signature at the 5p15 region associated with risk of prostate cancer

我们最近在澳大利亚男性中复制了一个区域(5p15)与前列腺癌风险的基因关联。我们现在试图确定这种关联背后的确切遗传变异，以及这些新基因/S和变异在疾病病理中的功能作用。我们的结果将为开发敏感和易于应用的基于实验室的筛查工具用于临床奠定基础，并通过加深我们对这种多因素疾病的理解，为药物靶向研究提供动力。

We have recently replicated the genetic association of a region (5p15) with the risk of prostate cancer in Australian men. We now seek to identify the precise genetic variant behind this association, and the functional role of these novel gene/s and variants in disease pathology. Our results will provide a foundation for the development of sensitive and readily applicable lab-based screening tools to be used clinically and will also provide impetus for drug-targeted research by furthering our understanding on this multifactorial disease.