Identification and characterisation of phosphorylation events taking place during human sperm capacitation

每20名澳大利亚男性中就有1人患有男性不育症，全世界所有不育夫妇中有三分之一患有男性不育症。人类不育最常见的原因不是不能产生精子，而是这些细胞不能表达正常的受精能力。这种功能丧失的原因尚不清楚。我们将利用我们在蛋白质组学方面的技术专长来描述不育患者中精子功能缺陷的分子途径。

Male infertility affects one in every twenty Australian males and one third of all infertile couples worldwide. The most common cause of human infertility is not a failure to produce sperm, but a failure of these cells to express a normal capacity for fertilization. The cause of this loss of functional competence is unclear. We are going to use our technical expertise in proteomics to characterize the molecular pathways responsible for the defective sperm function seen in infertile patients.