Personal Ozone Monitor

描述（由申请人提供）：在本提案中，我们响应国家环境健康科学研究所（NIEHS）在PHS 2007-2综合征集中的呼吁，“新产品/设备，工具，分析，以提高我们精确测量个人环境暴露的能力，具有高时空分辨率。”根据征求意见，该设备应具有适当的规模，以便现场部署和/或可穿戴。在光化学空气污染中形成的臭氧对人类健康有充分的不利影响，包括降低肺功能和加重先前存在的呼吸系统疾病，如哮喘。在高臭氧浓度期间，急诊科就诊次数、每日住院次数和死亡率增加。个人臭氧监测仪（POM）用于对臭氧的生理影响进行环境健康研究，并用于验证人体接触的计算机模型，例如环境保护局为协助制定国家空气质量标准而使用的空气污染接触（APEX）模型。我们建议开发一种小型（4 x 3 x 1英寸），重量轻（d 1磅），低功耗（d 3瓦），低成本（d $800零件）电池供电的POM基于完善的紫外线吸收方法。该仪器将进一步小型化背包大小的仪器，2B技术公司已经将其商业化，并成功地作为个人暴露监测仪进行了测试。口袋大小的POM将具有优于2 ppb的精度和准确度，并且每10秒进行一次新的测量。该仪器将有一个内部数据记录器和USB计算机接口，用于将数据下载到个人计算机。在第一阶段，我们将评估和选择小型化组件，设计和构建原型POM，测试原型的方向，振动和快速温度和湿度变化的影响，最后，根据线性，精度和准确度的分析数据对仪器进行表征。公共卫生相关性：将开发和测试一种口袋大小、电池供电的个人臭氧监测仪（POM）。POM将以公认的紫外线吸收方法为基础，将促进对空气污染中形成的臭氧对人体健康的不利影响进行生理学研究。

DESCRIPTION (provided by applicant): In this proposal we respond to the call by the National Institute of Environmental Health Sciences (NIEHS) in the PHS 2007-2 Omnibus Solicitation for "new products/devices, tools, assays to improve our ability to precisely measure environmental exposures to individuals with high temporal and spatial resolution." According to the solicitation, the device should be of appropriate scale to be field deployable and/or wearable. Ozone, formed in photochemical air pollution, has well documented adverse effects on human health, including reduction of lung function and aggravation of preexisting respiratory disease such as asthma. Emergency department visits, daily hospital admissions and mortality increase during episodes of high ozone concentration. A Personal Ozone Monitor (POM) is required for environmental health studies of the physiological effects of ozone and for validating computer models of human exposure such as the Air Pollution Exposure (APEX) model used by the Environmental Protection Agency to assist in establishing national air quality standards. We propose to develop a small (4 x 3 x 1 inch), light weight (d 1 lb), low power (d 3 watts), low cost (d $800 in parts) battery-operated POM based on the well established method of UV absorbance. The instrument will result from further miniaturization of a backpack-sized instrument already commercialized by 2B Technologies and successfully tested as a personal exposure monitor. The pocket-sized POM will have a precision and accuracy of better than 2 ppb and make new measurements every 10 s. The instrument will have an internal data logger and USB computer interface for downloading data into a personal computer. During Phase I, we will evaluate and select miniaturized components, design and construct a prototype POM, test the prototype for effects of orientation, vibration and rapid temperature and humidity change, and, finally, characterize the instrument with respect to the analytical figures of merit of linearity, precision and accuracy. PUBLIC HEALTH RELEVANCE: A pocket-sized, battery powered Personal Ozone Monitor (POM) will be developed and tested. The POM, which will be based on the well established method of UV absorbance, will facilitate physiological studies of the adverse effects of ozone, formed in air pollution, on human health.