CORE--TISSUE PROCUREMENT & DATA ANALYSIS & SERUM ANALYSIS

核心B的总体目标是为项目1-4的研究者提供定义明确的组织样本，并维护完整准确的交互式数据库。核心B获得组织并提供数据管理以支持项目。处理血液和粘膜样品用于实验使用和/或储存，收集相关临床数据并输入临床数据库。将组织样本与来自供体的临床和家族性状数据匹配，并与相关的免疫学和遗传参数交叉参考。采购技术员在医生访视时从临床和研究患者中采集样本，参加内窥镜手术以获取活检材料，并与医院外科医生和病理学家协调以从肠切除术中获取粘膜样本。将进行试验，以检测从项目研究或外部合作中收集的所有新小鼠和人血清中的微生物抗原抗体。协调基础科学研究的临床数据和结果，以便通过各种临床、亚临床、遗传和流行病学参数对人群进行分层。核心B提供的服务随着数据管理责任的增加而扩大，包括数据库管理和数据列报和实验开发的统计服务。核心鼓励多个研究者使用来自一个捐赠者的样本。核心服务已进一步扩展到临床试验支持以及临床研究的协调和翻译方面。两 核心人员中包括医生，并将与Cedars-Sinai综合临床研究中心合作提供额外的临床服务。研究协调员将帮助确定研究人群，提供设盲和随机化方案。还提供了统计分析。

The overall goal of Core B is to provide investigators of Projects 1-4 with well-defined tissue samples, and maintain a complete and accurate interactive database. Core B obtains the tissues and provides data management in support of the projects. Blood and mucosal samples are processed for experimental use and/or storage, and associated clinical data is gathered and entered into the clinical database. Tissue samples are matched with clinical and familial trait data from the donor cross-referenced with associated immunologic and genetic parameters. The procurement technician collects samples from clinical and research study patients at physician visits, attends endoscopic procedures to procure biopsy material and coordinates with hospital surgeons and pathologists to obtain mucosal samples from intestinal resections. Assays will be run to detect antibodies to microbial antigens on all new mouse and human sera collected from program project research or outside collaborations. Clinical data and results from basic science studies are coordinated to allow stratification of populations by a variety of clinical, subclinical, genetic and epidemiologic parameters. The services provided by Core B have expanded with the increase in data management responsibilities to include database management and statistical services for data presentation and experimental development. The Core encourages use of samples from one donor by several investigators. Core services have been further expanded to clinical trial support, and coordination and translational aspects of clinical research. Two physicians are included among the Core personnel and additional clinical services will be provided in cooperation with the Cedars-Sinai General Clinical Research Center. The Research Studies Coordinator will help to identify study populations, provide masking and randomization schemes. Statistical analysis is also provided.