CORE--Peptide Core

多肽核心通过以下活动为该计划项目提供高响应性的内部资源，用于多肽合成和化学分析服务和专业知识： 1.制备各种规模的合成肽和类似物，然后记录它们的同质性； 2.对多肽和生物合成产物进行测序、质谱分析和氨基酸组成分析； 3.开发和应用专门的化学程序，如交联剂、假体基团附着法和“定制”净化方式； 4.使用高效液相色谱和其他层析方式对蛋白质和多肽进行微观和宏观纯化 5.在合成和提纯策略方面的咨询和咨询，以及对 将技术提供给参与调查的人员。

The Peptide Core provides the Program Project with a highly-responsive, in-house resource for peptide synthesis and chemical-analytical services and expertise through the following activities: 1. Preparation of synthetic peptides and analogs over a range of scales, followed by documentation of their homogeneity; 2. Performance of sequencing, mass spectroscopy, and amino acid compositional analyses of peptides and biosynthetic products; 3. Development and application of specialized chemical procedures such as crosslinking, prosthetic group attachment and "customized" purification modalities; 4. Micro- and macro-scale purification of proteins and peptides using HPLC and other chromatographic modalities 5. Advice and consultation in synthesis and purification strategies and "hands-on" transfer of technologies to participating investigators.