ANTI-PROLIFERATIVE DRUGS IN PRIMATE MODELS

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 Cellgate拥有独特的多胺类似物专有库，其中两种正在进行临床肿瘤学试验。类似物具有独特的抗血管生成和抗增殖能力，可用于通过抑制可阻断血流的狭窄组织向内生长（内膜增生）来维持血管移植物通畅。因此，使用完善的血管移植物模型，将试验药物输注到临床血管移植物中，并使用适当的组织学和形态学技术评估其对内膜增生的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cellgate has a proprietary library of unique polyamine analogs, two of which are in clinical oncology trials. The analogs have unique antiangiogenic and antiproliferative capabilities that may be useful in maintaining vascular graft patency by inhibiting stenotic tissue ingrowth (intimal hyperplasia) that can block blood flow. Therefore, using a well-established vascular graft model, test agents will be infused into clinical vascular grafts and their effects on intimal hyperplasia will be assessed using appropriate histologic and morphometric techniques.