BEHAVIORAL GENOMICS OF ALCOHOL NEUROADAPTATION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在人类研究中，最初的敏感性及其与酒精使用障碍发展的关系通常是通过主观反应、运动协调或激素反应来衡量的(Farren和Tipton，1999；Heath，1999；Schuckit，2001)。有了这些措施，人类对酒精的低反应估计有0.4到06之间的遗传率。这项由朱迪·卡梅隆博士领导的研究项目旨在确定单次高剂量(2.0g/kg)乙醇对初生猴进行酒精诱导的共济失调的遗传性。这项研究是一项正在进行的针对年轻恒河猴的连锁研究，旨在确定对乙醇醉人效应敏感的基因，自2004年以来一直由PARC资助。我们的目标是确定最初对酒精的醉人效应的敏感性是否可以预测猴子成年后酒精自我给药的程度。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Initial sensitivity and its relation to the development of alcohol use disorders in human subject studies has most often been measured with subjective responses, motor in coordination, or hormonal response [Farren and Tipton, 1999; Heath, 1999; Schuckit, 2001]. With these measures, a low response to alcohol in humans has been estimated to have a heritability between 0.4 and 06. The research project headed by Dr. Judy Cameron is designed to determine heritability of alcohol-induced ataxia following a single high dose (2.0 g/kg) of ethanol in ethanol na¿ve monkeys This study is an ongoing linkage study in young rhesus monkeys designed to identify genes underlying sensitivity to the intoxicating effects of ethanol and has been funded through the PARC since 2004. Our goal is to determine if initial sensitivity to the intoxicating effects of ethanol can predict the extent of alcohol self-administration after the monkey has reached adulthood.