FUNCTIONAL BRAIN IMAGING IN BABOONS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们正在对狒狒进行PET成像，以量化行为挑战期间和之后局部大脑活动的个体差异。 狒狒将在SNPRC的单个笼子中过夜，然后在清醒时运送到UTHSC-SA的研究成像中心。 将通过SNPRC货车进行运输。 这种乘坐货车的经历会给动物带来轻微的压力，一旦它们到达成像中心，我们将量化杏仁核、前额皮质和其他大脑区域的大脑代谢的个体差异。 研究受试者将从先前研究中已测试对新奇反应的动物中选择。 因此，我们将能够选择一些对新奇事物具有高度反应性的动物，而另一些则更稳定，行为反应更少。 这将使我们能够确定哪些大脑区域在应对这种运输挑战时表现出最大的代谢活动差异，以及哪些大脑区域在挑战过程中的代谢活化与对新奇事物的行为反应之间表现出强烈的相关性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are conducting PET imaging of baboons to quantify individual differences in regional brain activity during and after a behavioral challenge. The baboons will be housed overnight in single cages, at SNPRC, and then transported while conscious to the Research Imaging Center at UTHSC-SA. Transportation will be by SNPRC van. This experience of riding in the van will be mildly stressful to the animals, and we will quantify individual differences in brain metabolism in the amygdala, prefrontal cortex and other regions of the brain once they arrive at the imaging center. Study subjects will be chosen from among animals already tested for response to novelty in a previous study. Therefore, we will be able to select some animals that score as highly reactivity to novelty and others that are more stable and less reactive behaviorally. This will allow us to determine which brain regions show the greatest variance in metabolic activity in response to this transportation challenge, and which brain regions show strong correlations between metabolic activation during challenge and behavioral responses to novelty.