P1: POTENTIAL OF SKIN STEM CELLS AND WOUND HEALING

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 最近的发现表明，来自特定器官的干细胞能够在其他器官中形成成熟组织，这改变了我们对干细胞在人类疾病和发育中所起作用的看法。骨髓干细胞是最具特性的干细胞之一，已被证明能够熟练地形成非血液组织。骨髓很可能为许多器官提供细胞底物，骨髓来源的祖细胞被招募到损伤或创面的区域。有证据表明，肝脏和心脏也是如此。了解这些骨髓细胞归巢和向皮肤募集的动态，对于开发各种疾病的治疗方法将是有价值的。我们已经在初步研究中表明，骨髓细胞可以植入伤口并形成皮肤结构。在对人类患者进行的一项临床研究中，我们有证据表明，骨髓可以加速愈合，并关闭在专门中心进行的其他传统和高级治疗未能愈合的慢性伤口。拟议中的研究将识别那些寄生于皮肤并形成皮肤结构的骨髓干细胞。纯化的骨髓干细胞和整个骨髓将被检测其植入和重建受伤皮肤结构的潜力。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Recent findings that stem cells from a particular organ are capable of giving rise to mature tissues in other organs have changed our thinking about the role of stem cells in human disease and development. Bone marrow stem cells are among the most well characterized stem cells and they have been shown to be proficient in forming non-blood tissues. It is likely that bone marrow provides the cellular substrates for many organs and that bone marrow derived progenitors are recruited to areas of injury or wounds. There is evidence of this for the liver and heart. Understanding the dynamics of homing and recruitment of these bone marrow cells to the skin will be valuable in developing treatments for a variety of disorders. We have shown in preliminary studies that bone marrow cells can engraft into wounds and form skin structures. In a clinical study performed on human patients, we have evidence that bone marrow can accelerate healing and close chronic wounds that have failed to heal by other traditional and advanced treatments administered in specialized centers. The studies proposed will identify those bone marrow stem cells that home to skin and form skin structures. Purified bone marrow stem cells and whole bone marrow will be examined for their potential to engraft and reconstitute skin structures in wounded skin.