Mentoring Neuroscience in Louisiana: A Biomedical Program to Enhance Neuroscience

描述（由申请人提供）：我们的COBRE，“在路易斯安那州指导神经科学：一个生物医学计划，以提高神经科学在一个ideA状态，”已经建立了科学卓越的文化在LSUHSC，杜兰大学，和高等教育的其他路易斯安那州机构。在这种环境下进行的神经科学研究在质量和生产力方面都有很大的协同作用;这种新的文化在我们机构的神经科学创新和根本重要的研究突破中发挥着关键作用。认识到指导过程对培养有前途的初级研究人员（PJI）和加强研究基础设施的重要性，我们现在提出一个机制，以进一步振兴指导过程，以巩固一个自我维持的系统，提高个人和集体的研究效率。通过我们的“指导文化”方法，我们建议（1）让所有参与COBRE资助的科学家参与开发一个全面的路易斯安那州神经科学中心;（2）支持PJIs的四个主要研究项目和五个试点项目;（3）继续支持和开发五个重要的核心设施;（4）继续加强路易斯安那州神经科学研究的质量。在我们的科学重点-突触可塑性，调节和功能的细胞和分子基础的背景下，PJIs的项目旨在为树突功能，神经信息处理以及与癫痫，缺血再灌注，耳聋和神经退行性疾病相关的神经保护机制提供见解。我们的七个COBRE核心资源-细胞生理学成像，分子生物学，计算神经科学，脂质组学，生物统计学，细胞生物学/组织培养和蛋白质组学-被选中支持这一科学重点。我们的COBRE指导计划-包括初级导师（成功的前PJIs）的导师团队-旨在在奖励的第二年内由PJIs制作R 01应用程序，并与招聘计划相结合，以吸引参与机构的新研究人员在第3年至第5年。我们的“补助金计划”旨在指导PJIs在申请和同行评审过程中具有竞争力。我们认为，四个目标教师，四个待招聘的教师，和额外的PJIs作为关键的基石，以加强和激励整个路易斯安那州强大的神经科学研究环境。

DESCRIPTION (provided by applicant): Our COBRE, "Mentoring Neuroscience in Louisiana: A Biomedical Program to Enhance Neuroscience in an IdeA State," has established a culture of scientific excellence at LSUHSC, Tulane University, and other Louisiana institutions of higher education. Neurosciences research performed in this environment is greatly synergized with respect to both quality and productivity; this new culture is playing a critical role in innovative and fundamentally important research breakthroughs in the neurosciences at our institutions. Recognizing the significance of the mentoring process for developing Promising Junior investigators (PJI) and for strengthening the research infrastructure, we now propose a mechanism to further invigorate the mentoring process in order to solidify a self-sustaining system that will enhance individual and collective research effectiveness. Through our "culture of mentoring" approach, we propose to (1) involve all participating scientists in the COBRE grant in the development of a comprehensive Louisiana Center for Neuroscience;(2) support four main research projects and five pilot projects by PJIs; (3) continue to support and develop five vital Core facilities; and (4) continue to strengthen the quality of neuroscience research in Louisiana. In the context of our scientific focus - Cellular and Molecular Bases of Synaptic Plasticity, Regulation, and Function - the PJIs' projects are designed to contribute insights into dendritic function, neural information processing, and mechanisms of neuroprotection relevant to epilepsy, ischemia-reperfusion, deafness, and neurodegenerative diseases. Our seven COBRE Core resources - Imaging of Cell Physiology, Molecular Biology, Computational Neurosciences, Lipidomics, Biostastitics, Cell Biology/Tissue Culture and Proteomics- are selected to support this scientific focus. Our COBRE mentoring plan - teams of mentors including junior mentors (successful former PJIs) - aims to produce R01 applications by the PJIs within the second year of the award, and is coupled with a recruitment plan to attract new research faculty at the participating institutions over Years 3 to 5. Our 'grantsmanship-plan' is designed to guide the PJIs to become competitive in the application and peer-review process. We view the four target faculty, the four to-be-recruited faculty, and additional PJIs as the critical building blocks to reinforce and energize a strong neuroscience research environment throughout the State of Louisiana.