MODEL OF INSP3 DYNAMICS IN DENDRITIC BRANCHLETS OF CEREBELLAR PURKINJE CELLS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 浦肯野神经元突触强度的长期抑制需要重复的肌醇-1，4，5-三磷酸（InsP3）介导的Ca2+释放，但InsP3受体，虽然高度丰富，是非常不敏感InsP3在这个细胞。突触输入发生在不同的结构，称为棘，这是ca。直径为15 m的球体通过窄颈连接到枝晶。脊柱分隔电信号和化学信号的能力知之甚少。我们正在利用这个项目来推动虚拟细胞新的电生理建模能力的发展。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Long term depression of synaptic strength in Purkinje neurons requires repeated inositol-1,4,5-trisphosphate (InsP3)-mediated Ca2+ release, but the InsP3 receptor, while highly abundant, is extraordinarily insensitive to InsP3 in this cell. Synaptic inputs occur at distinct structures, called spines, that are ca. 15m diameter spheres connected to the dendrite via a narrow neck. The ability of the spine to compartmentalize electrical and chemical signals is poorly understood. We are using this project to drive the development of new electrophysiological modeling capabilities of Virtual Cell.