Superfund Chemical Impact on Development

这项拟议的超级基金有害物质基础研究计划的主要主题是阐明人类和生态系统对特定超级基金化学物质的暴露机制和毒性，这些化学物质是根据其对发育影响的潜在重要性而选择的。该计划的主要目标如下：1)阐明选定的超级基金化学品和化学品混合物的发育毒性机制；2)促进通过与人类和/或生态健康有关的选定无脊椎动物和脊椎动物模型获得的机械信息的转移；3)利用微阵列方法评估模型正常和异常发育期间的基因表达，并增强这些模型的基因组数据库；4)开发高度敏感和有效的发育毒性标志物，可纳入人类健康和生态评估；5)阐明选定的超级基金化学品的微生物和光分解转化，这些化学物质增加了它们的环境命运和对发展的影响；6)利用地理信息系统（GIS）空间分析开发和传播北卡罗来纳州环境健康的预防性风险模型，重点关注儿童；7)有效地向科学、政府、商业和非专业社区的关键成员提供项目的研究成果；8)加强生物医学和环境科学领域的跨学科研究以及研究生和研究生培训。

The major theme of this proposed Superfund Hazardous Substances Basic Research Program is the elucidation of mechanisms of exposure and toxicity in humans and ecosystems to particular Superfund chemicals selected based upon their potential significance with respect to developmental effects. The major goals of the Program are as follows: 1) to elucidate mechanisms of developmental toxicity of selected Superfund chemicals and chemical mixtures; 2) to facilitate the transfer of mechanistic information obtained across selected invertebrate and vertebrate models relevant to human and/or ecological health; 3) to utilize microarray approaches for assessing gene expression during normal and perturbed development in our models, and enhance the genomic database for these models; 4) to develop highly sensitive and efficient markers for developmental toxicities that can be incorporated into human health and ecological assessments; 5) to elucidate microbial and photolytic transformations of selected Superfund chemicals that augment their environmental fate and effects upon development; 6) to use Geographic Information Systems (GIS) spatial analysis to develop and disseminate preventive risk models for environmental health in North Carolina, with an emphasis on children; 7) to effectively deliver the Program's research results to critical members of the scientific, governmental, business and lay communities; and 8) to enhance interdisciplinary research, and graduate and post-graduate training, in the biomedical and environmental sciences.