Hazardous Waste Risk and Remediation in the Southwest

这项提案的标题抓住了它的精髓--“危险废物的风险和补救 亚利桑那大学超级基金基础研究计划续签申请 建立在前一笔赠款成果的基础上。该计划的主题是支持 开发金属和有机污染物的风险评估程序，通过 毒物学和水文地质学研究，并通过开发创新的补救措施 技术。我们的申请强调了美国西南部的危险废物问题。 (和墨西哥边境)由于这种环境独特的干旱性质。然而，结果是， 我们的研究并不局限于西南地区，因为正在检测的主要毒物是砷 和卤代烃，在发达国家无处不在。我们的节目 包括10个研究项目-5个生物医学项目和5个环境科学 项目。许多项目是涉及多个学科的协作性项目。生物医学 项目正在研究目标组织中砷毒性的机制，影响 人群对砷毒性的易感性以及砷和三氯乙烯对 器官发育。环境科学项目正在调查危险程度 废物(砷、三氯乙烯/四氯乙烯)可以进行最佳表征，以进行补救和创新 在我们干旱的西南环境中控制或降解这些污染物的技术。 这些研究项目得到了五个核心的支持：管理计划，翻译 成果给利益相关者，提供研究服务，促进独特的外展努力 墨西哥，支持研究生培养。这个项目将有助于我们理解 国家和国际危险废物的毒理学和补救研究。

The title of this proposal captures its essence, "Hazardous Waste Risk and Remediation in the Southwest". The University of Arizona Superfund Basic Research Program renewal application builds on the achievements of the previous grant. The theme of this Program is to support development of a risk assessment process for metal and organic contaminants through toxicologic and hydrogeologic studies and through development of innovative remediation technologies. Our application emphasizes hazardous waste issues in the Southwestern U.S. (and Mexican Border) due to the unique arid nature of this environment. However, the results of our studies are not limited to the Southwest since the main toxicants being examined, arsenic and halogenated hydrocarbons, are ubiquitous throughout developed countries. Our Program consists of 10 research projects - five biomedical projects and five environmental sciences projects. Many of the projects are collaborative involving multiple disciplines. The biomedical projects are examining the mechanism of arsenic toxicity in target tissues, factors that affect the susceptibility of populations to arsenic-induced toxicity, and the effects of arsenic and TCE on organ development. The environmental sciences projects are investigating how hazardous wastes (arsenic, TCE/PCE) can be optimally characterized for remediation and innovative techniques for containing or degrading these contaminants in our arid Southwest environment. These research projects are supported by five Cores that: administer the Program, translate the results to the stakeholders, provide research services, promote unique outreach efforts to Mexico, and support graduate student training. This project will contribute to our understanding of toxicology and remediation of hazardous wastes nationally and internationally.