ROLE OF ION FLUXES DURING PATTERNING & EMBRYOGENESIS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们正在探索离子通量在脊椎动物两个发育阶段中的深刻作用：早期胚胎发育中左右轴的建立和模式，以及截肢附件再生过程中皮肤、肌肉、骨骼和脊髓的再生。(见SPID 0104)这两个过程都是令人着迷的问题，对于指导生物医学方法的设计至关重要，在LR模式的情况下，纠正出生缺陷(如左心发育不良综合征、异位、脾不全、多脾、大血管移位、内翻等)。它们共同影响着8000个新生儿中的1个，在再生的情况下，通过利用身体重建组织的潜在能力来替换患病或受损的组织。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are exploring the profound roles of ion fluxes during two vertebrate developmental stages: the establishment and patterning of the left-right (LR) axis during early embryogenesis, and the regeneration of skin, muscle, skeleton, and spinal cord during regeneration of an amputated appendage. (See SPID 0104) Both of these processes are fascinating as questions, and critically important for guiding the design of biomedical approaches to, in the case of LR patterning, correct birth defects (such as Hypoplastic Left Heart Syndrome, heterotaxy, asplenia, polysplenia, transposition of the major blood vessels, situs inversus, etc.) which together affect more than 1 in 8000 births, and, in the case of regeneration, to replace diseased or damaged tissue by harnessing the body's latent ability to recreate tissue.