BIRN: MOUSE BIOMEDICAL INFORMATICS RESEARCH NETWORK

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们继续MBIRN整合4个NIH国家资源的计算内部结构：杜克大学CIVM，加州大学洛杉矶分校的神经成像实验室和加州理工学院贝克曼研究所的MRI中心; NCMR和NBCR-都在UCSD。 MBIRN将提高正在进行的神经系统疾病基本小鼠模型合作的生产力： 1)多巴胺能系统改变的DAT基因敲除小鼠，使其成为研究精神分裂症、ADHD和物质滥用的理想模型; 2)EAE小鼠模型（化学诱导和转基因），其经历多发性硬化症的发作性虚弱和脱髓鞘特征。MBIRN将能够构建多尺度图像的可扩展联合数据库，包括MRM，冷冻切片的全脑，常规组织学，包括局部基因表达，具有蛋白质定位的3D亚细胞数据，以及来自透射电子显微镜（TEM）和即时高压电子显微镜的超分子图像数据。 3)在这项工作中开发的基础设施将为扩展到其他神经系统疾病的动物模型奠定基础。为这些特定动物模型开发的数据库将为这些模型提供新的见解，并作为BIRN合作伙伴研究中心小组在人脑结构成像方面开展的非侵入性成像工作的参考数据。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We continue MBIRN to integrate computational intrastructure of 4 NIH national resources: Duke CIVM, Lab of neurological imaging at UCLA with MRI center at Caltech's Beckman Institute; NCMIR, and NBCR---both at UCSD. MBIRN will enhance productivity of ongoing collaboration in basic mouse models of neurological disorders: 1) DAT knockout mouse with alterations in dopaninergic system, making it ideal for studies of schizophrenia, ADHD, and substance abuse; 2) EAE mouse models (both chemically induced and transgenic), which undergo episodic weakness and demylination characteristic of multiple sclerosis. MBIRN will enable construction of scalable federated databases of multi-scale images including MRM, cyrosectioned whole brains, conventional histology, including localized gene expression, 3D subcellular data with protein localization, and supramolecular image data from transmission electron microscopy (TEM) and immediate high voltage electron microscopy. 3) Infrastructure developed in the work will lay the foundation for extension to other animal models of neurologic disease. Databases developed for these specific animal models will provide new insight into these models and serve as reference data for non-invasive imaging work being undertaken by BIRN partner site group on human brain structure imaging.