STRUCTURAL NEUROIMAGING CORE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这一核心的主要目标是：1)通过提供有关大体脑形态的信息，协助研究参与者的特征，特别强调后期出现的神经解剖异常，以支持需要详细的区域神经解剖特征的研究；3)通过咨询支持；3)通过咨询和为试点研究生成sMRI数据，支持采用神经成像技术的新研究倡议，如磁共振波谱(MRS)、磁共振扩散成像和功能磁共振(FMRI)；4)在HNRC调查人员与两个相关的神经成像计划之间提供联系：(A)脑图像分析实验室(BIAL)，这是一个由多名研究人员组成的核心基础设施和培训计划，专注于功能磁共振成像在痴呆障碍中的应用(T.Jernigan，P.I.)；5)为附属于HNRC的学生和初级研究人员提供神经成像方面的指导、咨询和培训。该核心将支持正在进行的调查可在体内测量的艾滋病毒相关脑异常的性质和地区分布的工作(使用sMRI数据)，以及旨在开发更敏感和更有效的手段，通过其他神经成像手段(例如功能磁共振成像、磁共振波谱等)监测艾滋病毒相关中枢神经系统功能障碍的新工作。该核心还将专注于针对这一人群中存在的特定异常情况开发新的方法，包括开发更全自动的图像分析方法，以根据核磁共振成像体积评估大脑结构；绘制与CDC-C3状态相关的脑组织异常分布图，并最终与尸检证实的艾滋病毒脑炎(HIVE)相关；以及更复杂的方法，以表征脑白质中普遍存在的核磁共振异常。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objectives of this Core are: 1) To assist in characterizing study participants, by providing information about gross brain morphology, with a particular emphasis on neuroanatomical abnormalities present late in the capabilities to studies requiring detailed regional neuroanatomic characterization; 3) To support, with consultation; 3) To support, with consultation and generation of sMRI data for pilot studies, new research initiatives employing neuroimaging techniques, such as MR Spectroscopy (MRS), MR diffusion imaging, and functional MRI (fMRI); 4) To provide a liaison between HNRC investigators and two associated neuroimaging programs: (a) the Brain Image Analysis Laboratory (BIAL), a (REAP), a multi-investigator core infrastructure and training program focusing on applications of fMRI in dementing disorders (T. Jernigan, P.I.); 5) To provide mentorship, consultation, and training in neuroimaging to students and junior investigators affiliated with the HNRC. The Core will support ongoing work investigating the nature and regional distribution of HIV-related brain abnormalities measurable in vivo (with sMRI data), as well as new work aimed at developing more sensitive and more efficient means of monitoring HIV-related CNS dysfunction with other neuroimaging modalities (e.g., fMRI, MR Spectroscopy, etc.). The Core will also focus on new method development targeting the specific abnormalities present in this population, including the development of: more fully automated image-analytic methods for assessment of brain structure from MRI volumes; maps of the distribution of brain tissue anomalies associated with CDC-C3 status and ultimately, with autopsy-verified HIV encephalitis (HIVE); and more sophisticated methods for characterizing prevalent MRI abnormalities in cerebral white matter.