课题基金 / 基金详情

STRUCTURAL STUDIES OF BRCT RECOGNITION OF PHOSPHOPROTEINS

STRUCTURAL STUDIES OF BRCT RECOGNITION OF PHOSPHOPROTEINS
BRCT 磷酸蛋白识别的结构研究
批准号:
7721202
负责人:
NIKOLA P PAVLETICH
金额:
$0.97万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2008
资助国家:
美国
项目状态:
已结题
起止时间:
2008-05-15 至 2009-03-31

项目摘要

项目成果

NIKOLA P PAVLETICH的其他基金

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中文摘要
翻译
这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金, 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 BRCA2被认为是同源重组途径中的关键成分。我们已经展示了BRCA2的C末端是如何与单链DNA结合的。为了了解BRCA2的生理功能,我们想要确定BRCA2蛋白及其识别底物和相互作用伙伴的结构,包括RAD51。
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Brca2 is believed to be a critical component in homologous recombination pathway. We have shown how th c-terminal of Brca2 binds with single strand DNA. In order to understand its physiological function, we would like to determine structure of Brca2 protein with its recognized substrate and interacting partners, including rad51.
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