THE MULTIPLE ENDOCRINE NEOPLASIA TYPE I (MEN1) TUMOR SUPPRESSOR

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 多发性内分泌肿瘤是一种以内分泌组织肿瘤为特征的自体显性遗传性恶性肿瘤。导致这种恶性肿瘤的遗传机制与Menin肿瘤抑制基因的突变有关。尽管有丰富的遗传数据支持梅宁？S在甲型脑炎中的作用，但梅宁的生化功能仍不清楚。然而，最近的研究表明，Menin的肿瘤抑制功能在于它能够抑制许多促生长转录因子的转录活性，包括Jund、Smad3和NF-kB。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Multiple Endocrine Neoplasia Type (MEN) is an automsomal dominant malignancy that is characterized by tumors of endocrine tissues. The genetic mechanism responsible for this malignancy has been linked to mutations of the Menin tumor suppressor. Despite the wealth of genetic data that support Menin?s role in MEN1 disease, the biochemical function of Menin is still unknown. However, recent studies have demonstrated that the tumor suppressor function of Menin resides in its ability to repress the transcriptional activity of a number of growth-promoting transcription factors, including JunD, Smad3 and NF-kB.