Metal-Catalyzed Coupling Reactions

描述(由申请人提供)：用于生成碳-碳键的强大新方法的开发对需要合成有机化合物的广泛的学科(例如生物化学、药物化学和生物学)产生了影响。过渡金属可以催化碳-碳键的形成过程，例如有机亲电剂和亲核剂的交叉偶联，否则很难或不可能实现这一点。在下一次拨款期间，该计划将在很大程度上探索交叉偶联反应的维度-使用烷基亲电试剂作为底物的过程。努力将重点放在开发多功能催化剂上，包括手性催化剂，用于广泛的强大的键形成过程。这样的反应有可能同时产生碳-碳键，并定义多达两个新的立体中心。机理研究将在这个项目中发挥重要作用，因为对金属反应性的更好理解可以促进催化剂的开发。这一研究领域提供了一个令人兴奋的机会，对合成化学产生重大影响，并丰富我们对曾经意想不到的化学反应的理解。 公共卫生相关性：为了探索许多生物学问题和开发新的治疗化合物，需要能够有效地合成有机分子并控制目标化合物的手性(手性)。这项提议旨在解决这两个挑战。

DESCRIPTION (provided by applicant): The development of powerful new methods for the generation of carbon-carbon bonds has an impact on a wide array of disciplines that require the synthesis of organic compounds (e.g., biological chemistry, pharmaceutical chemistry, and biology). Transition metals can catalyze carbon-carbon bond-forming processes, such as cross-couplings of organic electrophiles and nucleophiles, that would otherwise be difficult or impossible to achieve. During the next grant period, this program will pursue a largely unexplored dimension of cross-coupling reactions-processes that employ alkyl electrophiles as substrates. Efforts will focus on the development of versatile catalysts, including chiral catalysts, for a wide range of powerful bond-forming processes. Such reactions have the potential to simultaneously generate a carbon-carbon bond and to define up to two new stereocenters. Mechanistic studies will play an important role in this project, since an improved understanding of metal-based reactivity could facilitate catalyst development. This research area offers an exciting opportunity to have a substantial impact on synthetic chemistry, as well as to enrich our understanding of once-unexpected chemical reactivity. PUBLIC HEALTH RELEVANCE: In order to probe many biological questions and to develop new therapeutic compounds, there is a need to be able to synthesize organic molecules efficiently and to control the chirality ("handedness") of the target compounds. This proposal is directed at addressing both of these challenges.