Diet, lifestyle and biological determinants of health and chronic diseases: the EPIC-Norfolk Prospective population study

随着人口老龄化，我们面临的一大挑战是如何保持健康，预防疾病和残疾。EPIC-Norfolk（诺福克欧洲癌症前瞻性调查）是一项对居住在东安格利亚的25,000名年龄在40-79岁之间的男性和女性进行的研究，他们提供了关于他们的健康和生活方式的详细信息，特别是1993-1997年的饮食和体育活动，并对他们进行了跟踪调查，以研究随着年龄的增长，哪些因素可以预测健康状况。这项研究旨在更好地了解如何预防和治疗许多与衰老相关的慢性疾病，如心脏病和中风、癌症、关节炎、糖尿病、呼吸系统疾病和骨质疏松症导致骨折，以及如何在晚年保持最佳健康。血液中新的生物标记物的测量，包括基因谱，也使我们能够更好地了解疾病的过程和进展，这可能有助于我们确定更好的治疗方法。我们将继续跟踪这项研究的参与者，在下一阶段，评估他们的身体和心理功能，以研究我们如何影响这些功能随着年龄的增长而发生的变化。

As the population ages, a major challenge is how we can maintain good health and prevent disease and disability. EPIC-Norfolk(European Prospective Investigation into Cancer in Norfolk) is a study of 25,000 men and women aged 40-79 years living in East Anglia who contributed detailed information on their health and lifestyle, in particular, diet and physical activity in 1993-1997 and who have since been followed up to examine what factors predict health as we age. This study aims to understand better how to prevent and treat many of the chronic diseases associated with ageing such as heart disease and stroke, cancer, arthritis, diabetes, respiratory disease and osteoporosis leading to fractures as well as how to maintain optimal health in later life. Measurements of new biologic markers in blood, including genetic profile, are also enabling us to understand better disease processes and progression, which may help us identify better treatments. We continuing to follow up the participants in this study and in the next phase, assess physical and mental function to examine how we can influence how these change as we age.