PRENATAL EXPOSURE TO MANGANESE AND ADHD-LIKE BEHAVIORS IN CHILDHOOD

描述(由研究人员提供)：注意缺陷多动障碍(ADHD)的病因尚不清楚，识别可改变的环境风险因素对于减少其发生率非常重要。锰既是一种基本的营养物质，在高水平下，也是普通人群普遍接触的一种潜在的神经毒物。这项研究的主要目的是使用新生儿行为评估量表(NBAS)和学龄儿童(中位数=8岁)的三种评估来调查产前MN与ADHD相关行为的关联：(1)临床诊断的ADHD；(2)用Conners教师评定量表评估的ADHD相关行为；以及(3)通过正式的心理测量测试测量与ADHD相关的行为，包括神经行为评估系统2连续操作测试和韦氏儿童智力量表第三版的组成部分。我们还将研究锰和铅(铅)在ADHD风险上的潜在协同作用。这项研究将在1993年至1998年期间出生的788名婴儿的出生队列中进行，这些婴儿的母亲住在马萨诸塞州新贝德福德一个被金属和多氯联苯污染的港口和超级基金所在地附近。在存档的脐带血样本中测量锰。相关性将通过多变量回归进行估计，并控制大范围的协变量。这项拟议的研究是迄今为止美国最大的一项研究，旨在评估产前锰对儿童随后神经行为的影响，并将受益于使用具有良好特征的人群，这些人群的发育自出生以来就进行了纵向评估，并可获得关于儿童发育不良风险因素的丰富信息。研究结果将对锰作为ADHD等常见行为障碍的潜在可补救危险因素的作用提供重要的见解。与公众健康相关：锰是一种天然存在的金属，既是一种基本的营养物质，也是潜在的神经毒物。本研究将探讨产前锰与儿童神经行为发育的关系，特别是与ADHD相关的行为。我们的发现将对MN作为这种日益常见且代价高昂的儿童行为障碍的潜在可补救危险因素的作用提供重要的见解。

DESCRIPTION (provided by investigator): The etiology of Attention Deficit Hyperactivity Disorder (ADHD) is poorly understood and identification of modifiable environmental risk factors is important for reducing its incidence. Manganese (Mn) is both an essential nutrient and, at high levels, a potential neurotoxicant to which the general population is commonly exposed. The primary aim of the proposed research is to investigate the association of prenatal Mn with behaviors associated with ADHD among infants using the Neonatal Behavioral Assessment Scale (NBAS), and among school-aged children (median=8 years) using three assessments: (1) clinically diagnosed ADHD; (2) behaviors associated with ADHD assessed with the Conners' Rating Scale for Teachers: and (3) behaviors associated with ADHD measured with formal psychometric tests, including the Neurobehavioral Evaluation System 2 Continuous Performance Test, and components of the Wechsler Intelligence Scale for Children-Third Edition. We will also investigate potential synergism between Mn and lead (Pb) on risk for ADHD. The study will be conducted among a birth cohort of 788 infants born between 1993 and 1998 to mothers residing adjacent to a metal- and PCB-contaminated harbor and Superfund site in New Bedford, Massachusetts. Mn is measured in archived cord blood samples. Associations will be estimated with multivariable regression, controlling for a wide range of covariates. The proposed study is the largest U.S. study to date to assess the effect of prenatal Mn on subsequent neurobehavior in children and will benefit from the use of a well characterized population whose development has been assessed longitudinally since birth and for whom a wealth of information on risk factors for adverse child development is available. Results will provide important insight into the role of Mn as a potentially remediable risk factor for common behavioral disorders such as ADHD. PUBLIC HEALTH RELEVANCE: Manganese (Mn) is a naturally occurring metal which is both an essential nutrient, and potential neurotoxicant. This study will investigate the association between prenatal Mn and childhood neurobehavioral development, particularly ADHD-related behavior. Our findings will provide important insight into the role of Mn as potentially remediable risk factor for this increasingly common and costly behavioral disorder of childhood.