Core A

核心A将为新型神经艾滋病疗法的所有项目和核心提供服务：临床前/临床综合疗法 IPCP将负责监督科学、行政、监管和业务方面的工作 该计划的活动。行政核心的总体目标是使IPCP能够履行其 科学任务，如本提案开头的导言和概述中所定义的，如规定的 在三个项目的具体目标中。首席调查员史蒂文·D·道格拉斯博士将指导这项工作 核心，并将为整个计划项目的工作和协助提供领导、指导和组织 每个项目负责人和核心负责人成功执行其计划的实验或 支持服务。行政核心的目标是：(1)协调和监督这一IPCP； (2)通过协调定期审查研究结果和整合，监督IPCP的发展计划 将这些信息纳入决策进程，这对联合国毒品和犯罪问题办公室的药物开发任务是不可或缺的 研究计划；(3)促进各国之间高度合作和协同互动 调查员和核心领导人；(4)促进该IPCP参与NIH IPCP方案活动；(5) 确保个别项目有效和适当地使用核心服务；(6)提供调查人员和 掌握有关核心和项目支出及资源的及时和准确信息的核心董事； (7)确保项目的开发计划符合所有适用的法规 准则和国家卫生研究院的政策和程序；(8)组织和实施经常性的内部和外部 监督IPCP的活动；以及，(9)支持该方案履行与以下方面有关的义务 信息发布、科学出版、数据共享。这将包括管理 与印章技术转让部门合作解决知识产权问题。这个 行政核心将由所有参与的项目和科学核心平等使用。

Core A will serve all projects and cores in the Novel neuroAIDS Therapies: Integrated Preclinical/Clinical IPCP and will be responsible for oversight ofthe scientific, administrative, regulatory and operational aspects of the program's activities. The overall goal of the Administrative Core is to enable the IPCP to fulfill its scientific mission, as defined in the introduction and overview at the beginning of this proposal, as a specified in the Specific Aims of the three projects. The Principal Investigator, Dr. Steven D. Douglas, will direct this core and will provide leadership, direction, and organization to the overall program project effort and assist each of the Project Leaders and Core Leaders in the successful execution of their planned experiments or support services. The objectives ofthe Administrative Core are to: (1) Coordinate and supervise this IPCP; (2) Oversee the development plan ofthe IPCP by coordinating regular review of study results and integration of this information into the decision-making process that is integral to the drug development mission of the research program; (3) Promote a high degree of collaboration and synergistic interaction among the investigators and core leaders; (4) Facilitate participation of this IPCP within NIH IPCP Program activities; (5) Insure efficient and appropriate use of core services by the individual projects; (6) Provide investigators and core directors with timely and accurate information regarding core and project expenditures and resources; (7) Insure that the program's development plan is conducted in compliance with all applicable regulatory guidelines and NIH policies and procedures; (8) Organize and implement regular internal and external oversight of the IPCP's activities; and, (9) Support the program in fulfilling its obligations related to information dissemination, scientific publication and data sharing. This will include management of intellectual property issues in collaboration with the CHOP Department of Technology Transfer. The Administrative Core will be utilized equally by all participating projects and scientific cores.