Substance use among adolescent and young adult Hispanic cancer survivors

描述（由申请人提供）：虽然治疗进展提高了儿童癌症的存活率，但大多数幸存者随后经历了显著的早期发病率和死亡率。因此，建议儿童癌症幸存者（CCS）避免使用物质（酒精，烟草，大麻），以潜在地延迟或减轻癌症治疗相关的晚期效应。然而，由于先前的工作主要是基于1986年之前诊断的患者，我们对最近治疗的CCS的健康行为的了解程度尚不清楚。此外，我们对西班牙裔癌症幸存者的了解特别有限，因为这一种族在研究工作中的代表性不足。本研究的目的是确定最近接受治疗的西班牙裔和非西班牙裔CCS（年龄14-25岁）中物质使用（酒精，大麻和烟草）的风险和保护因素，包括文化因素（例如，适应美国），心理社会（例如，压力），家庭（例如，凝聚力和冲突），以及人口统计学（例如，收入、教育）因素。为了探索癌症经历对西班牙裔人群物质使用的潜在影响，将比较西班牙裔CCS与年龄和性别匹配的非癌症西班牙裔对照（从青少年的单独队列研究中获得）之间的物质使用率。研究结果将指导改进健康教育材料的开发，以防止CCS中的物质使用，包括西班牙裔CCS的潜在独特方法。 公共卫生相关性：我们对最近接受治疗的儿童癌症幸存者（CCS）的健康行为的了解程度尚不清楚，因为以前的工作主要是基于1990年之前诊断的患者。此外，我们对西班牙裔癌症幸存者健康行为的了解特别有限，因为这一种族在研究工作中的代表性不足。本研究的目的是检查最近接受治疗的西班牙裔CCS的物质使用行为（酒精，大麻和烟草），以提供有关改善这些行为的适当方法的重要信息，并最终提高CCS的长期生存率。

DESCRIPTION (provided by applicant): Although treatment advances have increased the survival rates for childhood cancer, most survivors subsequently experience significant early life morbidity and mortality. Thus, childhood cancer survivors (CCS) are recommended to avoidance substance use (alcohol, tobacco, marijuana), to potentially delay or mitigate cancer treatment-related late effects. However, because prior work has been largely based on patients who were diagnosed before 1986, the extent of our knowledge regarding the health behaviors of recently treated CCS is unclear. Further, our understanding of Hispanic cancer survivors is especially limited due to under representation of this ethnic group in research efforts. The purpose of this study is identify risk and protective factors of substance use (alcohol, marijuana, and tobacco) among recently treated Hispanic and non-Hispanic CCS (ages 14-25), including cultural (e.g., acculturation to the U.S), psychosocial (e.g., stress), family (e.g., cohesion and conflict), and demographic (e.g., income, education) factors. To explore the potential impact of the cancer experience on substance use among Hispanics, rates of substance use between Hispanic CCS and age and gender matched non-cancer Hispanic controls (obtained from a separate cohort study of adolescents) will be compared. Results will guide the development of improved health education materials to prevent substance use among CCS, including potential unique approaches for Hispanic CCS. PUBLIC HEALTH RELEVANCE: The extent of our knowledge regarding the health behaviors of recently treated childhood cancer survivors (CCS) is unclear because prior work has been largely based on patients who were diagnosed before 1990. Further, our understanding of health behaviors among Hispanic cancer survivors is especially limited due to underrepresentation of this ethnic group in research efforts. The purpose of this study is to examine the substance use behaviors (alcohol, marijuana, and tobacco) of recently treated Hispanic CCS to provide vital information on appropriate methods to improve these behaviors and ultimately, long term survival of CCS.