CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCH

该子项目是对CTSA供资的百分比的估计， 用于广泛的研究领域（艾滋病研究，儿科研究，或 临床试验）。 列出的总成本仅为CTSA金额的估算 用于该研究领域的基础设施，而不是直接提供的资金 向子项目或子项目工作人员提供NCRR补助金。 哥伦比亚大学医学中心（CUC）的CTSA计划将改变临床和转化（C/T）研究的文化，使我们能够培养和留住优秀的高级教师干部，领导下一代的C/T研究人员。在中央情报局的大力支持下-赫伯特欧文 捐赠将从目前的1500万美元增加到2500万美元，我们将通过创建欧文临床和转化研究所（ifCTR）来实现我们的目标。IICTR将成为下一代C/T调查人员的学术和知识之家。卢旺达问题国际法庭将拥有一支由高级和初级C/T调查员组成的优秀队伍，他们将领导开发的资源，以履行RM-06-002中定义的关键职能。高级教员将为卢旺达问题国际法庭提供领导和地位，并担任初级教员和卢旺达问题国际法庭受训人员的导师。初级教师，称为欧文研究员，将由CMEC基金（$450，000/y）的支持，并将与高级教师合作，开发新的方法来打破多学科和跨学科（M& I）C/T研究的障碍。欧文学者将成为M& I研究应在CMEC进行的方式的榜样，IICTR提供的资源，包括在生物医学信息学，生物伦理学，监管问题，患者导向的研究和核心资源方面的杰出支持和研究，将使我们能够推动这些变化。欧文研究员将得到卢旺达问题国际法庭提供的试点和合作研究赠款（每年700 000美元）。卢旺达问题国际刑事法庭将有35 000平方英尺的空间，包括6 000平方英尺的新建空间，用于在卢旺达问题国际刑事法庭进行住院/门诊研究。（300万美元），为临床导向研究教育中心提供2,200平方英尺的新空间（100万美元），这将是我们的学员和教师的家，以及一个新的校外研究中心，以支持基于社区的C/T研究和教育（100万美元）。我们已经创建了一个综合教育计划，其中包括一个新的多学科患者 面向研究（MPQR）硕士学位，一个新颖的K12学者M& I研究指导研究计划，以及一个开创性的MPOR博士学位计划。将定期跟踪和评估CTSA的所有活动。 儿科和社区为基础的G/T研究将得到特别关注。卢旺达问题国际法庭和反恐安全局将打破阻碍新知识从法官席向临床和社区传播的障碍。

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. Columbia University Medical Center's (CUMC) CTSA program will transform the culture of clinical and translational (C/T) research so that we can develop and retain an outstanding cadre of senior faculty to lead the next generation of C/T investigators. With outstanding support from the CUMC - Herbert Irving Endowment, which will increase from its present level of $15 million to $25 million dollars, we will accomplish our goal by creating the Irving Institute for Clinical and Translational Research (ifCTR). The IICTR will be the academic and intellectual home for the next generation of C/T investigators. The IICTR will have an outstanding faculty of senior and junior C/T investigators who will lead Resources developed to carry out the Key Functions defined in RM-06-002. The senior faculty will provide leadership and stature for the IICTR, and serve as mentors for both the junior faculty and IICTR trainees. The junior faculty, called Irving Fellows, will be supported by CUMC funds ($450,000/y) and will work with senior faculty to develop novel approaches to breaking down the barriers to multi- and interdisciplinary (M&l) C/T research. The Irving Scholars will be role models for the way M&l research should be conducted at CUMC, and the Resources provided by IICTR, including outstanding support and research in biomedical informatics, bioethics, regulatory issues, patient oriented research, and core resources, will allow us actuate those changes. The Irving Fellows will be supported by CUMC as will pilot and collaborative research grants awarded by the IICTR ($700,000/yr). The IICTR will have 35,000 sq ft of space, including 6,000 sq ft of newly constructed space for inpatient/outpatient research at CUMC ($3 million), 2,200 sq ft of new space for the Center for Clinically Oriented Research Education ($1 million) that will be a home for our trainees and faculty, and a new off-campus research center to support community-based C/T research and education ($1 million). We have created an integrated eductional program that includes a new multidisciplinary patient oriented research (MPQR) Master's degree, a novel K12 Scholars Mentored Research Program in M&l research, and a pioneering MPOR PhD program. All CTSA activities will be tracked and evaluated regularly. Pediatric and community-based G/T research will receive special attention. The IICTR and CTSA will break down the barriers impeding movement of new knowledge from the bench to the bedside and community.