ctsa infrastructure for clinical trials

该子项目是对CTSA供资的百分比的估计， 用于广泛的研究领域（艾滋病研究，儿科研究，或 临床试验）。 列出的总成本仅为CTSA金额的估算 用于该研究领域的基础设施，而不是直接提供的资金 向子项目或子项目工作人员提供NCRR补助金。 杜克建议建立一个临床转化科学研究所（CTSI）。该研究所将实现四个具体目标：1）创建一个研究所，通过支持创造性的转化研究团队，将基本发现转化为改善的医疗保健。该研究所将为原始转化和临床研究提供领导和资源，并将开发和执行有关转化和临床科学的新方法和方法的研究。2)创造一个环境，使各级学员，包括医学和护理学校的学生，物理治疗师，药理学家，内务人员，研究员，研究生，初级教师和职业过渡教师可以在转化和临床研究培训。培训将建立在这样的原则上，即丰富的临床和转化研究环境将为杜克学员提供成功的模式和机会。3)通过促进杜克的部门，研究所，中心和学校之间的合作，利用现代生物信息学和旨在整合生物过程的密集测量的新临床研究单位支持的人力资源，整合转化和临床科学。4）开发一个社区模型，了解如何使用先进的信息学和卫生服务提供方法将研究结果从实验室转化为床边人口。杜克CTSI将建立在三个实体或支柱上，包括杜克转化研究所（DTRI）、杜克临床研究所（DCRI）和杜克社区研究中心（DCCR）。这三个实体将汇集并扩展现有项目，并将旨在强调从基础科学实验室开始的研究范围沿着连续性，并以改变个体患者结果的新疗法结束。这三大支柱（DCRI、DTRI和DCCR）将在行政上加入新的杜克临床和转化科学研究所（杜克CTSI），这是本申请的核心。这个新的研究所将与其他关键项目，包括杜克综合癌症中心，杜克大学护理学院和杜克基因组科学与政策研究所，为临床和转化研究人员创造一个全面的家。CTSI的创建与公共卫生密切相关，因为它将创造一个环境，促进更快地向社区提供新的干预措施和医疗保健实践。

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. Duke proposes to create a Clinical Translational Science Institute (CTSI). This institute will accomplish four specific aims: 1) To create an institute that will transform how fundamental discoveries are translated into improved medical care by supporting creative translational research teams. The institute will provide leadership and resources for original translational and clinical research, and it will develop and perform studies regarding novel methods and approaches to translational and clinical science. 2) Create an environment in which trainees at all levels, including medical and nursing school students, physical therapists, pharmacologists, house staff, fellows, graduate students, junior faculty and career transition faculty can be trained in translational and clinical research. The training will be built on the principle that a rich clinical and translational research environment will provide Duke trainees with models and opportunities for success. 3) Integrate translational and clinical science by fostering collaboration among Duke's departments, institutes, centers, and schools using human resources supported by modern bioinformatics and a new clinical research unit designed to integrate intensive measurements of biological processes. 4), Develop a community model for understanding how to translate the findings of research from bench to bedside to populations using advanced informatics and health services delivery methods. The Duke CTSI will be founded on three entities, or pillars, including the Duke Translational Research Institute (DTRI), the Duke Clinical Research Institute (DCRI), and the Duke Center for Community Research (DCCR). These three entities will bring together and expand existing programs, and will be designed to emphasize the continuities along the spectrum of research that begins in a basic science laboratory and concludes with novel therapies that change outcomes for individual patients. These three pillars (DCRI, DTRI, and DCCR) will be administratively joined into the new Duke Clinical and Translational Science Institute (Duke CTSI), the core of this application. This new institute will link With other key programs, including the Duke Comprehensive Cancer Center, the Duke University School of Nursing, and the Duke Institute for Genome Sciences and Policy, to create a comprehensive home for clinical and translational researchers. The creation of the CTSI is patricianly relevant to public health as it will create an environment that will foster speedier delivery of new interventions and healthcare practices to the community.