Tenth and Eleventh International Symposia on Neurobiology and Neuroendocrinology

第十届和第十一届神经生物学和神经内分泌学老龄化国际研讨会将于2010年7月25日至30日和2012年7月在奥地利布雷根茨举行。这些会议的目的是将最近在衰老机制研究方面取得重大进展的一组研究人员聚集在一起，特别强调中枢神经系统衰老，神经保护和神经退行性疾病的治疗。具体的主题将包括IGF-1在大脑中的作用，内皮功能中的shc蛋白，线粒体调节蛋白，氧化应激和神经肌肉连接。两场讲座将专门讨论生殖激素在衰老过程中作用的最新进展。有关衰老机制的讲座也将包括从进化蛋白质组学适应的角度介绍衰老与抗逆性关系的新数据。讨论与中枢神经系统衰老相关的机制将包括下丘脑激素在痴呆中的作用，阿尔茨海默病病理的应激性迟缓以及改善阿尔茨海默病患者认知的治疗方法。关于神经保护机制的讲座包括从蠕虫到人类常见的神经退行性机制和极端长寿的神经生物学。我们特意包括了广泛的主题，并召集了一群通常不会参加同一次会议的科学家。会议的形式以戈登研究会议为蓝本，鼓励对所提交的材料进行正式和非正式的讨论。会议记录将在研讨会后大约六个月内作为《实验老年学》的特刊发表。强烈鼓励包括研究生和博士后在内的初级研究人员的参与，本提案寻求资金为那些正在接受培训或处于初级教师职位的美国参与者提供津贴，并计划在海报会议上展示他们的研究成果。我们还在寻求部分支持，以支付美国邀请发言者的费用。

DESCRIPTION (provided by applicant): The Tenth and Eleventh International Symposia on Neurobiology & Neuroendocrinology Aging will be held in Bregenz, Austria July 25-30, 2010 and in July 2012. The purpose of these meetings is to bring together a group of investigators who made recent significant advances in the study of mechanisms of aging, with particular emphasis on CNS aging, neuroprotection and treatment of neurodegenerative disease. Specific topics will include the roles of IGF-1 in the brain, shc proteins in endothelial function, mitochondrial regulator proteins, and oxidative stress and the neuromuscular junction. Two lectures will specifically address recent advances in understanding the role of reproductive hormones in aging. Lectures dealing with the mechanisms of aging will also include presentation of new data on the relationship of aging to stress resistance from an evolutionary proteomic adaptation perspective. Discussion of mechanisms specifically related to aging of the CNS will include the roles hypothalamic hormones in dementia, stress-induced retardation of Alzheimer's disease pathology and a therapeutic approach to improve cognition in Alzheimer's disease patients. Lectures about neuroprotective mechanisms include neurodegenerative mechanisms common from worm to man and neurobiology in extreme longevity. We purposely include a wide range of topics and assemble a group of scientists that may not normally attend the same meeting. The format of the meeting is modeled after Gordon Research Conferences and encourages formal and informal discussions of the material presented. Proceedings will be published as a special issue of Experimental Gerontology within approximately six months after the Symposium. Participation of junior investigators, including graduate students and post-doctoral fellows is strongly encouraged and this proposal seeks funds for providing stipends to those US participants who are in training or are in junior faculty positions and who are planning to present their findings in the poster session. We are also seeking partial support for the expenses of invited speakers from the United States.