2008 Chromatin Structure and Function Gordon Research Conference

描述(由申请人提供)：该提案寻求获得题为“染色质结构和功能”的第21届戈登研究会议(GRC)的部分资金。自1972年成立以来，“染色质”GRC在建立和维护对染色质有重要兴趣的不同科学家群体之间的沟通与合作方面发挥了核心作用。这次会议旨在促进我们对染色质结构在基因组功能中的作用的理解。这是一个快速发展的研究领域，与人类健康，特别是癌症和发育障碍的相关性越来越大。会议的焦点是染色质及其在调控中的作用，已经演变成一个将非常基础的科学与包括临床试验在内的转化性研究联系起来的话题。会议的主要目的是通过促进信息、思想、概念和方法的国际和跨学科交流，促进研究人员之间的跨大西洋交流。染色质GRC在催化美国和世界其他地方的研究人员之间的大量富有成效的互动方面有着良好的记录，特别是在欧洲，那里也建立了非常强大的染色质社区。会议的第二个重要目标是提高科学家在职业生涯早期的潜力。会议系列仍然是最受欢迎的GRC之一，超额认购了两倍多，2006年的申请比2004年增加了50%。会议的成功是因为该领域仍在扩大，每年都有令人兴奋的发现，这反映在一个以最新发展为特色的项目中。即将到来的会议将特别强调将染色质描述为一个复杂的结构系统，它涉及微调真核基因组的功能及其沿着增殖和分化途径的编程和重新编程。

DESCRIPTION (provided by applicant): This proposal seeks to obtain partial funding for the 21st Gordon Research Conference (GRC) entitled "Chromatin Structure and Function." Since its inception in 1972, the "Chromatin" GRC has played a central role in establishing and maintaining communication and collaboration among the diverse group of scientists with a vital interest in chromatin. The conference seeks to advance our understanding of the role of chromatin structure in the functioning of genomes. This is a fast evolving research area with increasing relevance for human health, notably cancer and developmental disorders. The focus of the meeting, chromatin and its role in regulation, has evolved into a topic that connects the very basic sciences to translational research including clinical trials. The prime aim of the conference is to foster the transatlantic communication between researchers by facilitating an international and interdisciplinary exchange of information, ideas, concepts and methodology. The Chromatin GRC has an excellent track record of catalysing a large number of fruitful interactions between researchers in the United States and others elsewhere in the world, particularly in Europe, where a very strong chromatin community has also been established. The second important aim of the conference is to enhance the potential of scientists early in their careers. The conference series remains one of the most popular GRCs, more than two-fold oversubscribed with an increase in applications of 50% in the year 2006 relative to 2004. The success of the meeting is due to the fact that the field is still expanding and exciting discoveries are being made each year, which are reflected by a program that features the most recent developments. The upcoming conference will put special emphasis on describing chromatin as a complex system of structures that are involved in fine-tuning the functioning of the eukaryotic genome and its the programming and reprogramming along pathways of proliferation and differentiation.