Genetics of Reproductive Senescence

女性生殖衰老的标志是卵巢功能、月经规律的进行性丧失 和内分泌动态平衡。生殖老化伴随血管舒缩和泌尿生殖系统症状 在绝经事件本身之前，并可导致病理生理综合征，包括 骨质疏松症和心血管疾病。非人灵长类动物的种群和遗传学研究将 加强我们对围绝经期--更年期过渡的理解。南美SFBR中的雌性狒狒 尤其是提供了一个独特的模型来理解人类的生殖衰老，因为我们可以准确地 根据会阴肿胀来决定它们终生的月经行为，和人类一样，它们是非季节性的 饲养员。该项目将研究个体月经动态，以量化生殖衰老状态 对于大量研究人群中的所有女性，它将生成每日个体多周期的详细概况 促性腺激素和类固醇激素。这些措施将提供基于个人的估计 估计环境、母体和遗传成分对变异的贡献的种群规模 生殖老化，并确定影响生殖模式和围绝经期的遗传基因座。这个 数据将为评估围绝经期的机械模型提供独特的机会。再加上 项目范围内身体衰老的多维测量，我们将评估生殖的程度 和躯体衰老是一致的，也是独立的。

Female reproductive senescence is marked by the progressive loss of ovarian function, menstrual regularity and endocrine homeostasis. Reproductive aging is accompanied by vasomotor and urogenital symptoms preceding the event of menopause itself, and can contribute to pathophysiological syndromes including osteoporosis and cardiovascular disease. Population and genetic studies of nonhuman primates will enhance how we understand perimenopause - the menopausal transition. Female baboons of SFBR in particular offer a unique model to understand human reproductive aging because we can accurately determine their life-long menstrual behavior from perineum turgescence and, like humans, are non-seasonal breeders. This Project will study individual menstrual dynamics to quantify the state of reproductive senescence for all females of the large study population, and it will generate detailed profiles of daily individual multi-cycle gonadotropic and steroid hormones. These measures will provide individual based estimates on a population scale to estimate the contribution of environment, maternal and genetic components to variation reproductive aging, and to identify genetic loci that influence reproductive patterns and perimenopause. The data will provide unique opportunities to evaluate mechanistic models for perimenopause. Coupled with the program-wide multidimensional measures of somatic aging, we shall evaluate the extent that reproductive and somatic aging are concordant or independent.