Training in Signal Transduction and Cellular Endocrinology

描述（由申请人提供）： 这一竞争性的更新是为现在10岁的信号转导培训计划（STTP）在伊利诺伊大学芝加哥。STTP提供信号转导，基因转录和翻译以及细胞内分泌学方面的跨学科博士前培训，重点关注抑制信号和调节细胞，组织和有机体发育以及环境和免疫反应的细胞和分子机制。目标是在信号转导和细胞内分泌学的广泛方面培养博士前候选人，以培养独立的基础科学家和临床研究人员。过去十年的STTP主题是促进教师研究人员和计划之间的培训环境互动，这些计划使用不同的实验系统和方法来了解生物组织各级的信号转导机制，包括分子，细胞和整体生物学。STTP跨学科，部门和学院线，从六个基础科学部门的35名教师的专业知识（解剖学与细胞生物学、生物化学与分子遗传学、微生物学与免疫学、药理学、生理学与生物物理学和生物工程）和四个临床部门（血液肿瘤学、内分泌学和代谢学、肺部和重症监护、泌尿学），利用广泛的分子、生物化学、生理学、遗传学、结构和动物模型综合生物学方法，提供信号转导和相关领域广泛问题的培训机会。信号转导，膜受体，第二信使，细胞周期调控，基因转录，癌症生物学，哺乳动物发育，内分泌和神经体液信号是STTP教师的主要优势。博士前培训包括理论，技术和研究观点，通过教学课程，研究报告，研讨会，研究轮换和非正式的互动。信号转导，内分泌学的专业课程以及UIC医学科学（GEMS）跨学科研究生教育计划的核心课程，包括分子和细胞生物学，生物化学，遗传学，结构生物学，生理学，药理学，科学交流和负责任的研究行为，为密集的研究培训环境提供了基础。教师培训师的研究兴趣范围从神经体液信号，膜受体和第二信使，细胞周期控制，转录，翻译和表观遗传基因调控，发育和结构生物学。STTP强调当代信号转导和细胞内分泌学研究的跨学科性质，培养独立和创造性思维的环境，并有助于产生独立的研究人员，他们现在在这一广泛的领域做出了重大贡献，并开始丰富科学进步和科学研究界。

DESCRIPTION (provided by applicant): This competitive renewal is for the now 10-year old Signal Transduction Training Program (STTP) at the University of Illinois at Chicago. The STTP provides interdisciplinary predoctoral training in signal transduction, gene transcription and translation, and cellular endocrinology, with strong emphasis on cellular and molecular mechanisms that transduce signals and regulate cell, tissue and organismal development, and environmental and immunologic responses. The goal is the training of predoctoral candidates in broad aspects of signal transduction and cellular endocrinology to develop independent basic scientists and clinical investigators. An STTP theme for the past ten years is the promotion of training environment interactions between faculty researchers and programs that are using different experimental systems and approaches to understand signal transduction mechanisms at various levels of biological organization including molecular, cellular and integrative whole organism biology. The STTP crosses disciplinary, departmental and college lines, drawing upon the expertise of 35 faculty from six basic science departments (anatomy & cell biology, biochemistry & molecular genetics, microbiology & immunology, pharmacology, physiology & biophysics and bioengineering), and four clinical sections (hematology-oncology, endocrinology and metabolism, pulmonary and critical care, urology), offering training opportunities in wide ranging problems in signal transduction and allied areas using a broad spectrum of molecular, biochemical, physiologic, genetic, structural and animal model integrative biology approaches. Signal transduction, membrane receptors, second messengers, cell cycle regulation, gene transcription, cancer biology, mammalian development, endocrine and neurohumoral signaling are major strengths of the STTP faculty. Predoctoral training includes theory, techniques and research perspectives through didactic courses, research presentations, seminars, research rotations and informal interactions. Specialized courses in signal transduction, endocrinology, and a core curriculum in the interdisciplinary Graduate Education in Medical Sciences (GEMS) program at UIC in molecular and cellular biology, biochemistry, genetics, structural biology, physiology, pharmacology, scientific communication and responsible conduct of research provide the foundation for an intensive research training environment. Faculty trainer research interests range from neurohumoral signaling, membrane receptors and second messengers, cell cycle control, transcriptional, translational and epigenetic gene regulation, developmental and structural biology. The STTP emphasizes the interdisciplinary nature of contemporary research in signal transduction and cellular endocrinology in an environment fostering independent and creative thinking, and is contributing to the generation of independent investigators who are now making significant contributions in this broad area, and who beginning to enrich scientific progress and the scientific research community.