Research Training in Infections and Immunity

描述(由申请人提供)：这项NRSA竞赛申请将允许贝勒医学院(BCM)的学员继续成功地开展传染病的临床研究事业。目前，我们是BCM或德克萨斯医学中心内唯一一家从事非艾滋病感染临床研究培训的NRSA。BCM在许多领域都有极好的培训机会。具有良好联邦资助和培训经验的参与项目包括：1)先天免疫和医院感染，2)基于药物、细胞和益生菌的新型治疗，3)病毒和细菌性胃肠炎，4)病毒和细菌致病和肿瘤发生，5)急性呼吸道病原体和肺炎，6)疫苗开发和评估，7)结核病，8)假体感染。2007年，对参与该NRSA计划的特定中心和项目的赠款支持总额为1950万美元。该计划的结构包括三个部分，代表了受训人员可以进行的培训途径：1)基于实验室的临床研究，2)临床研究试验和3)临床流行病学。所有以实验室为基础的实习生将被要求参加BCM的临床科学家培训计划(CSTP；K30)；医生实习生将获得临床研究硕士学位。那些从事临床流行病学研究的学生必须进入德克萨斯大学-休斯顿公共卫生学院(UTHSPH)，并获得公共卫生硕士学位。那些从事临床试验的学员将进入CSTP或UTHSPH，并分别获得硕士或公共卫生硕士学位。BCM的成人传染病培训方案表明，它可以吸引高素质的博士后学员，其中一半以上是女性，近四分之一是代表不足的少数族裔，并为他们提供在传染病临床研究领域开始成功职业生涯所需的技能。在当前周期中，该方案已有5名实习生毕业，他们都被任命为主要医学院或大学的助理教授级别。这些人总共发表了60篇同行评议的原创手稿，并获得了几项享有盛誉的拨款和职业发展奖，总额达160万美元。这一成功记录，加上申请者人数翻了一番，以及10名新的教师导师/联合导师的参与，作为支持续签的证据，每年有3名博士后实习生，比目前周期的2名实习生有所增加。

DESCRIPTION (provided by applicant): This NRSA competing application will allow trainees at Baylor College of Medicine (BCM) to continue to successfully launch clinical research careers in infectious diseases. At this time, ours is the sole NRSA existing within BCM or the Texas Medical Center to pursue clinical research training in non-AIDS infections. Superb training opportunities exist at BCM in a number of areas. Participating projects with a strong record of federal funding and training experience include: 1) Innate Immunity and Nosocomial Infections, 2) Novel Drug-, Cell- and Probiotic-based Therapeutics, 3) Viral and Bacterial Gastroenteritis, 4) Viral and Bacterial Pathogenesis and Oncogenesis, 5), Acute Respiratory Pathogens and Pneumonia, 6) Vaccine Development and Evaluation, 7) Tuberculosis, and 8) Prostheses Infections. Total grant support in 2007 for the specific centers and programs participating in this NRSA Program is $19.5M. The structure of the Program contains three components, representing training tracks that can be pursued by trainees: 1) laboratory-based clinical research, 2) clinical research trials and 3) clinical epidemiology. All trainees pursuing the laboratory-based track will be required to participate in the Clinical Scientist Training Program (CSTP; K30) at BCM; physician trainees will obtain their MS in Clinical Investigation. Those pursuing the clinical epidemiology track are required to enter the University of Texas-Houston School of Public Health (UTHSPH) and obtain their MPH. Those trainees pursuing the clinical trials track will enter either the CSTP or UTHSPH and obtain their MS or MPH, respectively. The Adult Infectious Diseases Training Program at BCM has shown it can attract highly qualified postdoctoral trainees, over half of them women and close to a quarter under-represented minorities, and provide them with the skills necessary to begin successful careers in infectious diseases clinical research. In the current cycle, this Program has graduated 5 trainees, all of whom were appointed to the Assistant Professor level in a major medical college or university. Altogether, these individuals have published 60 original peer-reviewed manuscripts and have been awarded several prestigious grants and career development awards, totaling $1.6M. This record of success, along with a doubling in the pool of applicants and the participation of 10 new Faculty Mentors/Co-Mentors, is offered as evidence in support of renewal with 3 postdoctoral trainees per year, an increase from 2 trainees in the current cycle.