COBRE: Center for Cardiovascular Research

描述(申请人提供)：科布雷：心血管研究中心 我们向夏威夷大学(UH)生物医学研究卓越中心(COBRE)提交这份续签申请，以回应美国国立卫生研究院RFA-RR-06-001。约翰·A·伯恩斯医学院已经招募了一位新的PI来提交更新，他是R01资助的分子心脏病专家Ralph Shohet博士。我们计划建立在第一个Cobre周期的基础科学基础上，并将Cobre的重点放在心血管疾病的跨学科研究上。我们修改了我们的申请，以回应审查员的建议，并侧重于夏威夷现有资源和人员的实力。Shohet博士建立了心血管研究中心(CCR)，并挑选了具有广泛科学专业知识的UH研究人员，将他们的研究努力与心血管重要问题联系起来。初级研究人员的项目都将探索与临床疾病相关的心血管应激模型。每个研究人员都找到了非常合格的本地和外部导师来指导他们的研究和职业发展。我们的主要目标是通过扩大心血管研究的跨学科中心来加强大学的生物医学研究能力，并增强UH调查人员竞争独立外部资金的能力。我们将通过四个具体目标来实现这一目标：1)扩大CCR；2)支持初级研究人员；3)加强指导活动；以及4)通过新的小鼠表型核心和已建立的组织学和基因组学核心来增强研究能力。我们的长期目标是为技术熟练的研究人员队伍做出贡献，他们的研究最终将有助于减少夏威夷不同种族群体，特别是夏威夷原住民和其他太平洋岛民的心血管健康差距。

DESCRIPTION (provided by applicant): COBRE: Center for Cardiovascular Research We are submitting this renewal application for the Center of Biomedical Research Excellence (COBRE) at the University of Hawaii (UH) in response to the National Institutes of Health RFA-RR-06-001. The John A. Burns School of Medicine has recruited a new PI for the submission of this renewal, Dr. Ralph Shohet, an R01-funded molecular cardiologist. We plan to build upon the basic science foundation of the first COBRE cycle and direct the COBRE's emphasis toward interdisciplinary research in cardiovascular disease. We have modified our application to respond to the reviewers' suggestions and focused upon the strength of resources and personnel already present in Hawaii. Dr. Shohet has established a Center for Cardiovascular Research (CCR) and selected UH investigators with a broad range of scientific expertise, linking their research efforts to problems of cardiovascular importance. Junior investigators' projects will all explore models of cardiovascular stress that are pertinent to clinical disease. Each investigator has identified highly qualified local and external mentors to guide their research and career development. Our primary objective is to strengthen the university's biomedical research capacity through the expansion of an interdisciplinary center for cardiovascular research and enhance the ability of UH investigators to compete for independent extramural funding. We will accomplish this objective through four specific aims: 1) expand the CCR; 2) support junior investigators; 3) enhance mentoring activities; and, 4) augment research capacity through a new mouse phenotyping core and established histology and genomics cores. Our long-term goal is to contribute to the cadre of skilled researchers whose studies will ultimately contribute to reduction of cardiovascular health disparities in diverse ethnic groups in Hawaii, particularly Native Hawaiians and other Pacific Islanders.