Free Radical Cancer Biology Program

自由基癌症生物学计划的研究重点是癌症中的氧化事件，包括自由基，细胞氧化还原状态和抗癌药物，辐射和其他类型的抗癌治疗的影响。该计划成员的总体目标是确定操纵细胞氧化还原状态的方法，以改善癌症治疗，并了解与肿瘤疾病相关的氧化变化。 该方案的研究中有四个主要的重叠主题。 主题1 -了解氧化和亚硝化事件和信号在癌症生物学中的作用。 主题2 -使用抗氧化酶、自由基或氧化策略的调节增强癌症治疗 主题3 -一氧化氮在癌症生物学和癌症治疗中的作用 主题4 -了解为什么肿瘤更频繁，有时随着年龄的增长有不同的生物学。 自由基癌症生物学计划在过去的资助期内的主要成就包括：（a）AdMnSOD转导是人类口腔癌动物模型的有效治疗方法， (b)一氧化氮增强阿霉素对恶性乳腺癌细胞的细胞毒性，但对恶性乳腺癌细胞没有增强作用。 心脏细胞，（c）DNA甲基化在建立和/或维持细胞类型特异性基因表达中起作用，（d）老年动物缓冲急性应激后细胞内产生的潜在有害氧化剂的能力减弱，和（e）抗氧化酶磷脂谷胱甘肽过氧化物酶通过改变过氧化物张力影响细胞的生长速率。过去和现在，该计划的成员之间以及与其他癌症中心计划的成员之间都有许多富有成效的合作。例如，癌症治疗中氧化事件的计划项目资助以及我们参与的衰老和癌症P20涉及许多成员，并且具有高度的互动性和计划性。自由基癌症生物学计划由来自9个部门和2个学院的17名成员组成。同行评审，该计划的研究资金总额为2，230，523美元，其中1，624，781美元来自NCI。

Research in the Free Radical Cancer Biology Program focuses on oxidative events in cancer, including free radicals, cell redox state and effects of anticancer drugs, radiation and other types of anticancer therapy. The overall goals of the members of this program are to identify ways of manipulating cellular redox state to improve cancer therapy and to understand the changes in oxidation associated with neoplastic disease. There are four major overlapping themes within the Program's research. Theme 1 - Understanding the role of oxidative and nitrosative events and signaling in cancer biology. Theme 2 - Augmenting cancer therapy using modulation of antioxidant enzymes, free radicals or oxidative strategies Theme 3 - The role of nitric oxide in cancer biology and cancer treatment Theme 4 - Understanding why neoplasia is more frequent and sometimes has a different biology as we age. The major accomplishments of the Free Radical Cancer Biology Program over the past funding period include the findings that (a) AdMnSOD transduction is an effective treatment for animal models of human oral cancer, (b) nitric oxide augments cell cytotoxicity of doxorubicin for a malignant breast cancer cell, but not for a cardiac cells, (c) there is a role for DNA methylation in the establishment and/or maintenance of cell-type specific gene expression, (d) there is a blunted ability in old animals to buffer potentially harmful oxidants being produced within a cell following an acute stress, and (e) that the antioxidant enzyme phospholipid glutathione peroxidase influences the growth rate of cells by altering the peroxide tone. There are numerous past and present productive collaborations both between members of the Program, and with members of other Cancer Center programs. For example, the Program Project Grant in Oxidative Events in Cancer Therapy and our participation in the Aging and Cancer P20 involve many members and are highly interactive and programmatic. The Free Radical Cancer Biology Program consists of 17 members from 9 departments and 2 colleges. Peer-reviewed, research funding for this program totals $2,230,523 with $1,624,781 coming from the NCI.