HEMISPHERIC SPECIALIZATION AND COMMUNICATION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在本报告所述期间，我们的实验室专注于对黑猩猩的下额回(IFG)(与Broca区同源)的体积和偏侧化的活体和死后分析。 我们发现，从磁共振图像测量的IFG很好地符合Brodmann区44区(BA44)的细胞结构分布，但不符合Brodmann区45区(BA45)细胞的结构分布。因此，IFG只是Broca区一个细胞部分的同源记录。BA45细胞似乎定位于紧靠额眶沟前方的脑回。根据细胞数据创建了BA44和BA45的概率图，并将其应用于48只黑猩猩样本的灰质体积分割。 我们发现BA44有显著的向左不对称性，BA45有显著的向右不对称性。此外，BA45不对称性的变异与黑猩猩的口面部运动控制有关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. During the reporting period our laboratory focused on the in vivo and post-mortem analysis of the volume and lateralization of the inferior frontal gyrus (IFG) (the homolog to Broca's area) in chimpanzees. We found that the IFG as measured form magnetic resonance images corresponds well to the cytoarchitectural distribution of Brodmann's area 44 (BA44) but not Brodmann's area 45 (BA45) cells. Thus, the IFG is the homlog to only one cellular portion of Broca area. BA 45 cells appear to localize in the gyrus immediately anterior to the fronto-orbital sulcus. Probabilistic maps of BA44 and BA45 were created based on the cellular data and applied to segmented grey matter volumes in a sample of 48 chimpanzees. We found significantly leftward asymmetries for BA44 and significant rightward asymmetries of BA45. Moreover variation in the asymmetries of BA45 were associated oro-facial motor control in the chimpanzees.