AMYGDALA-ORBITAL FRONTAL INTERACTION AND REWARD EXPECTANCY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在灵长类动物中，眼眶额叶皮质(ORB)或杏仁核(AMYG)的损伤导致使用积极或消极结果来指导行为反应的缺陷。然而，它们在灵活的目标导向行动中各自扮演的角色仍然不确定。 该项目的目的是改进和实施可逆失活的使用，通过冷却，达到灵长类认知功能的精确神经底物。在这个项目中，这项技术将允许区分ORB和AMYG在猴子解释视觉刺激的强化价值并根据学习的偏好和当前动机状态自适应地改变选择反应的能力中所扮演的角色。 已经购买了两只猴子，并完成了行为训练，正在等待冷却探头的建造以供植入。此时，他们将恢复训练。由于制造微型探头的困难，我们联系了埃默里和佐治亚理工学院的几名工程师，帮助我们设计探头。这些探头目前正在建造中，并将在今年进行冷却试验。我们相信，这些探头将成为研究大脑功能的强大工具。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Orbital frontal cortex (ORB) or amygdala (AMYG) damage in primates yields deficits in using positive or negative outcomes to guide behavioral responses. Yet, their respective role in flexible goal-directed actions remains uncertain. The purpose of this project is to refine and implement the use of reversible inactivation, via cooling, to the precise neural substrate of cognitive functions in primates. For this project, the technique will allow to distinguish the role of ORB and AMYG in monkeys' ability to interpret the reinforcing value of visual stimuli and alter adaptively their choice responses upon both learned preferences and current motivational state. Two monkeys have been purchased and have completed the behavioral training and are awaiting the construction of the cooling probe to be implanted. At this time, they will resume training. Because of the difficulty in constructing the microprobes, we have contacted several engineers here at Emory and at Georgia Tech to help us with the design of the probes. The probes are now under construction and will be tested for their use in cooling experiment in the present year. We feel confident that the probes will be a powerful tool to study brain functioning.