NEW FACULTY RECRUITMENT IMAGE-GUIDED CANCER THERAPEUTICS

描述（由申请人提供）：凯斯西储大学（CWRU）的生物医学工程系（BME）将转化研究，纳米技术以及生物医学和放射成像的发展视为其愿景和使命的一部分。通过招聘一名终身助理教授，我们寻求通过利用纳米控制制造纳米颗粒来研究“图像引导癌症治疗”，以设计多功能药物，促进癌症治疗的诊断，治疗和监测。当今的癌症治疗方法采用“一刀切”的方法来给药和给药，必须探索新的改进的治疗策略，这些策略将技术部分结合起来，从而可以实现定制的患者特异性治疗策略。具体来说，我们建议招聘一名终身教职员工，以帮助在CWRU团结工程，成像和癌症专业知识的全方位。这样一个计划将利用现有的优势，药物输送，纳米技术和成像组件的BME部门，案例中心成像研究，以及精湛的医学和基础研究发生在医学院，和病例综合癌症中心开发一个非常合作的计划，旨在临床翻译和开发新的成像工具，作为改善患者治疗的推动者-通过非侵入性询问肿瘤脉管系统状态的特定方式。 为了实现这些目标，该计划将利用工程方法，包括计算机，体外和体内研究。重要的是，这些工具可以作为其他疾病的平台技术，其中脉管系统状态和完整性的知识非常重要（例如动脉粥样硬化，缺血）。该项目的目标是开发翻译和临床相关的成像技术，这些技术可以非侵入性地检测和监测（1）癌症状态，（2）以患者特异性方式预测和监测抗癌药物的效果。该计划将进一步促进快速增长的纳米技术，癌症治疗和成像，以及俄亥俄州的医疗行业。除了对医疗保健的重大影响外，该计划还可能促进俄亥俄州创造就业机会和长期经济影响。 公共卫生相关性（由申请人提供）：当今的癌症治疗采用“一刀切”的方法，必须探索新的改进的、可定制的疗法。通过招聘助理教授，该计划旨在将纳米技术与临床相关成像相结合，以患者特定的方式提供治疗的预后和监测工具，使肿瘤学家能够更好地选择差异化治疗方案。

DESCRIPTION (provided by applicant): The Department of Biomedical Engineering (BME) at Case Western Reserve University (CWRU) views translational research, nanotechnology, and development of biomedical and radiologic imaging as part of its vision and mission. Via the recruitment of a tenure-track Assistant Professor, we seek to investigate "Image-Guided Cancer Therapeutics" by exploiting the nanoscale control in fabricating nanoparticles to design multifunctional agents that facilitate diagnosing, treating and monitoring of cancer therapies. Today's cancer therapeutics take a 'one-size-fits-all' approach to dosage and delivery of drugs, and new improved therapeutic strategies have to be explored that incorporate the technological pieces of a puzzle that can lead to customized, patient-specific therapeutic strategies. Specifically, we propose to recruit a tenure track faculty member to help unite the full spectrum of engineering, imaging and cancer expertise at CWRU. Such a program will exploit the existing strengths of the drug delivery, nanotechnology and imaging components of the BME Department, Case Center for Imaging Research, and the superb medical and basic research occurring at the School of Medicine, and the Case Comprehensive Cancer Center to develop an extremely collaborative program aimed at clinical translation and development of novel imaging tools as enablers of improved therapies in a patient-specific manner via non-invasive interrogation of tumor vasculature status. To achieve these goals, the program will utilize engineering approaches including in silico, in vitro and in vivo studies. Importantly, these tools can serve as platform technologies for other diseases where knowledge of vasculature status and integrity is of great importance (e.g. atherosclerosis, ischemia). The goal of the proposed program is to develop translational and clinically-relevant imaging technologies that non-invasively can detect and monitor (1) cancer status and (2) predict and monitor the effects of anticancer drugs in a patient-specific manner. This program will further contribute to the fast growing nanotech, cancer therapy and imaging, and medical industries of Ohio. Besides the significant impact on healthcare, this program can potentially facilitate job creation and long-term economic impacts for Ohio. PUBLIC HEALTH RELEVANCE (provided by applicant): Today's cancer therapeutics take a 'one-size-fits-all' approach, and new improved, customizable therapies have to be explored. Via the recruitment of an Assistant Professor, this program aims to integrate nanotechnology with clinically-relevant imaging to provide prognostic and monitoring tools of treatments in a patient-specific manner that enables oncologists to better differentially select therapeutic regimens.