Biostatistics and Bioinformatics Core

得克萨斯大学淋巴瘤孢子项目的生物统计学和生物信息学核心。 D.安德森癌症中心将成为临床和基础科学设计的综合资源 实验，数据采集和管理，开发创新的统计方法， 生物信息学分析，并通过淋巴瘤孢子产生的翻译研究出版 程序. 生物统计学和生物信息学核心将在每个实验中纳入合理的实验设计原则。 这些项目是针对正在解决的科学问题的。每个项目都将提供量身定制的 分析，伴随着适当的（有时是新的）统计发展。为首一 核心委员会将定期与项目调查人员会晤。这些会议的目的是讨论设计 进行新的和现有的研究项目，评估分析结果，并讨论潜在的新的 在SPORE内的研究计划和方向。生物统计学和生物信息学的核心领导人也将 与项目调查人员合作，确定可用于测试研究假设的定量测量方法 并确定样本量，以确保研究有足够的把握度。此外，生物统计学和 生物信息学核心将与所有项目研究人员合作，以促进所有数据的及时发布 根据SPORE研究计划收集。 生物统计学和生物信息学核心的主要目标是： 1.为研究和临床提供统计设计，包括样本量和功效计算 项目 2.提供所有统计数据分析，包括描述性分析、假设检验、估计和 对预期生成的数据进行建模。 3.为所有项目生成统计报告。 4.开发和调整与生物标志物整合翻译相关的创新统计方法 淋巴瘤研究。 5.提供高通量、高维数据的生物信息学数据分析。 6.协助所有项目研究人员发表科学成果。

The Biostatistics and Bioinformatics Core for the Lymphoma SPORE program at The University of Texas M. D. Anderson Cancer Center will be a comprehensive resource for design of clinical and basic science experiments, data acquisition and management, developing innovative statistical methodology, bioinformatics analysis, and publishing translational research generated through the Lymphoma SPORE program. The Biostatistics and Bioinformatics Core will incorporate sound experimental design principles within each project that are specific to the scientific issues being addressed. Each project will be provided with tailored analyses, accompanied by appropriate (and sometimes novel) statistical development. The leader of this core will meet regularly with project investigators. The purposes of these meetings are to discuss the design and conduct of new and existing research projects, evaluate results of analyses, and discuss potential new research initiatives and directions within SPORE. The Biostatistics and Bioinformatics Core Leader will also work with project investigators to identify quantitative measures that can be used to test study hypotheses and to determine sample sizes to ensure sufficient power for the studies. In addition, the Biostatistics and Bioinformatics Core will collaborate with all project investigators to facilitate the timely publication of all data collected under the SPORE research program. The main objectives of the Biostatistics and Bioinformatics Core are: 1. To provide statistical designs, including sample sizes and power calculations, for research and clinical projects. 2. To provide all statistical data analysis including descriptive analyses, hypothesis testing, estimation, and modeling of prospectively generated data. 3. To generate statistical reports for all projects. 4. To develop and adapt innovative statistical methods pertinent to biomarker-integrated translational lymphoma studies. 5. To provide bioinformatics data analysis of high-throughput and high dimensional data. 6. To collaborate and assist all project investigators in the publication of scientific results.