Neurocircuitry underlying effective DBS for OCD

强迫症的脑深部刺激靶点集中在腹侧内囊，腹侧 纹状体。这一建议的假设是刺激的行为影响会随着电极的不同而不同 位置，由于不同地激活上升和下降的前额叶环路的子组件。 我们的实验室正在开发光纤连接和终端的3-D图集，其基础是从 用于描绘和比较终端场和纤维束位置的传统轨迹跟踪方法 来自特定的皮质区域。这些数据将被用来开发皮质纤维如何移动的模型 通过内囊，预测哪些结构最有可能受到影响 每个刺激点。我们将用它来检验扩散张量成像采集和分析的有效性 算法，并探索将我们的发现扩展到人类的能力。有三个目标：目标1将描绘 前额叶皮质和皮质下纤维束穿过IC不同区域的过程 和VS。目标2将确定哪些捆绑包可能是最有效的影响目标站点 回避-奖励冲突行为，以及它们连接的大脑区域；目标3将确定该网络 在VCA/S内的DBS期间被激活。P2将通知和被通知在 中心。通过与P1、3、4和5的协作，我们将深入了解哪些路径(和结构) 参与可能与强迫症相关的回避、奖励和灭绝行为。结果来自 AIMS 1和AI2将影响PI-5刺激部位的选择。目标3将通知，也将被告知， 作为机制基础的啮齿动物激活模型(P4-6)。总体而言，结合对猴子的追踪， 在猴子和人类中的DTI，以及计算方法将为进一步研究 构成回避的通路和终端场组织的解剖学原理 和奖励。 相关性(请参阅说明)： 强迫症(OCD)是一种慢性精神疾病，影响全球2%-3%的人 人口。这就是疾病是十大康复疾病之一。这项研究将检查神经 与强迫症相关的行为背后的网络和机制。这些行为不仅限于 强迫症，但与一系列情感和成瘾障碍有关。集体建议的研究 将产生新的假说，即这些大脑网络中的功能障碍是如何通过 并提供对正常行为反应背后的机制的洞察。

The deep brain stimulation target for OCD is centered in the ventral internal capsule, and the ventral striatum. The hypothesis of this proposal is that the behavioral impact of stimulation will vary with electrode location, due to differentially activating subcomponents of the ascending and descending prefrontal circuits. Our laboratory is developing a 3-D atlas of fiber connections and terminals, based on data collected from conventional track tracing methods to delineate and compare of terminal fields and fiber bundle locations from specific cortical regions. This data will be used to develop a model for how cortical fibers travel through the internal capsule leading, to predictions about which structures are most likely be affected for each stimulation site. We will use it to test the validity of diffusion tensor imaging acquisition and analytic algorithms, and explore the ability to extend our findings to humans. There are 3 aims: Aim 1 will delineate the course of prefrontal cortical and subcortical fiber bundles that pass through different regions of the IC and VS. Aim 2 will determine which bundles are likely to be the most effective target sites for affecting avoidance-reward conflict behaviors, and the brain regions they connect; Aim 3 will identify the network activated during DBS within the VCA/S. P2 will inform and be informed by all the proposed projects in the Center. In collaboration with P1, 3, 4, & 5, we will gain insight into which pathways (and structures) are involved in avoidance, reward, and extinction behaviors that may be associated with OCD. Results from aims 1 & 2 will impact on the choice of stimulation sites used in PI-5. Aim 3 will inform, and be informed by, rodent models of activation that underlie the mechanisms (P4-6). Overall, combining tracing in monkeys, DTI in monkeys and humans, and computational methods will provide a blueprint for further studies of the anatomical principles that underlie the organization of pathways and terminal fields involved in avoidance and reward. RELEVANCE (See instructions): Obsessive Compulsive Disorder (OCD) is a chronic psychiatric illness that affects 2-3% of the worldwide population. This is disease is in the top ten dehabilitating diseases. This study will examine the neural network and mechanisms that underlie behaviors associated with OCD. These behaviors not limited to OCD, but are associated with a range of affective and addictive disorders. The collective proposed studies will generate new hypotheses of how dysfunctions within these brain networks are expressed across diseases and provide insight into the mechanisms underlying normal behavioral responses.