NEUROBIOLOGY OF ANOREXIA AND BULIMIA NERVOSA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的1：我们预测，相对于对照女性(CW)，在禁食和进食状态下，REC AN的前脑岛(AI)和眼眶额叶皮质(OFC)对蔗糖(相对于离子水)的反应将减弱，而REC BN的反应将被夸大，这表明存在异常的动态平衡。 目的2：我们预测，相对于CW，在REC AN中，相对于离子水，AI/OFC对糖的反应的变化将在REC AN中减弱，在REC BN中被夸大，当摄食状态与禁食状态相比较时，这表明对饥饿的动态平衡反应发生了改变。 目的3(探索性)：我们将探索饥饿是否增加了BN的焦虑，降低了AN的焦虑，以及焦虑的变化是否与AI激活有关。我们将探索REC、AN和BN是否存在与摄食行为调节无关的奖赏和认知功能障碍。我们还将确定认知和行为数据是否与神经功能发现相关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. AIM 1: We predict that, relative to control women (CW), anterior insula (AI) and orbital frontal cortex (OFC) response to sucrose (relative to ionic water) will be diminished in REC AN and exaggerated in REC BN in both the fasting and fed states, indicating an aberrant homeostatic tone. AIM 2: We predict that, relative to CW, the change in AI/OFC response to sugar relative to ionic water will be diminished in REC AN and exaggerated in REC BN, when the fed state is compared to the fasting state, suggesting an altered homeostatic response to hunger. AIM 3 (exploratory): We will explore whether hunger increases anxiety in BN and decreases anxiety in AN, and whether anxiolytic changes are associated with AI activation. We will explore whether REC AN and BN have disturbances of reward and cognitive function that are independent of modulation of feeding behaviors. We will also determine whether cognition and behavioral data correlate with neuro-functional findings.